Production of proteases type plasminogen activator and their inhibitor in cornea
| Autor: | M. Mirshahi, J. Soria, A. Thomaidis, Claudine Soria, Y. Pouliquen, Jean-Pierre Faure, Shah Sultan Mirshahi |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Proteases
medicine.medical_treatment Biophysics Biochemistry Tissue plasminogen activator Epithelium Cornea Plasminogen Activators Fibrinolytic Agents Culture Techniques Fibrinolysis medicine Animals Secretion Endothelium Molecular Biology Glycoproteins Urokinase Activator (genetics) Chemistry Cell Biology Urokinase-Type Plasminogen Activator Cell biology Plasminogen Inactivators medicine.anatomical_structure Tissue Plasminogen Activator Cattle Endothelium Vascular Plasminogen activator medicine.drug |
| Zdroj: | Biochemical and Biophysical Research Communications. 160:1021-1025 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/s0006-291x(89)80104-4 |
| Popis: | Corneal epithelial cells secrete tissue plasminogen activator (t-PA), urokinase type plasminogen activator (u-PA) and their inhibitor (PAI), whereas these cell types in other tissues are known to secrete only u-PA hitherto. Endothelial cells in the cornea produce mostly u-PA and only small amounts of t-PA and PAI which remain confined in the cellular compartment contrary to the situation in the vascular endothelial cells where they are liberated into the circulation in the order PAI greater than t-PA greater than U-PA. These unique features of activator/inhibitor secretion and production may play an important role in the remodeling of the corneal matrix. |
| Databáze: | OpenAIRE |
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