Analog computer analysis of a model-system for the induced enzyme synthesis
| Autor: | F. Heinmets |
|---|---|
| Rok vydání: | 1964 |
| Předmět: |
Statistics and Probability
chemistry.chemical_classification General Immunology and Microbiology biology Applied Mathematics Analog computer Value (computer science) Repressor General Medicine Models Theoretical General Biochemistry Genetics and Molecular Biology Enzymes law.invention Reaction rate constant Enzyme Biochemistry chemistry law Modeling and Simulation biology.protein Inducer Enzyme inducer General Agricultural and Biological Sciences Biological system Function (biology) |
| Zdroj: | Journal of Theoretical Biology. 6:60-75 |
| ISSN: | 0022-5193 |
| DOI: | 10.1016/0022-5193(64)90066-9 |
| Popis: | A method has been developed for the analysis of induced enzyme synthesis by the use of a model-system. Analog computer techniques are used to calculate the relative magnitudes of various operational components as a function of time. The most basic entities of the system are regulatory and functional genes and for these a value of “unity” is assigned. By designating suitable pool values and rate constants, transient concentrations for repressor, messenger, and template are determined. Enzyme formation as a function of time is recorded at various inducer concentrations. Pulsed induction on an analog computer is used to simulate experiments in the laboratory. Several mechanisms of enzyme induction are analyzed by modifying the general model-system. The effect of various pool concentrations and rate constants on the rate of enzyme synthesis has been studied. The results suggest that model-systems can be usefully applied to explore the basic mechanisms of enzyme synthesis. |
| Databáze: | OpenAIRE |
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