Manumycins E, F and G, new members of manumycin class antibiotics, from Streptomyces sp
| Autor: | Kevin J. Volk, Steven E. Klohr, Yue-Zhong Shu, Richard R. Wang, Pramathesh S. Patel, Prabhavathi B. Fernandes, Stella Huang, Kin Sing Lam, Dolores M. Pirnik, J. C. Wells |
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| Rok vydání: | 1994 |
| Předmět: |
Pharmacology
Magnetic Resonance Spectroscopy biology Spectrophotometry Infrared Stereochemistry Chemistry Streptomycetaceae Biological activity Microbial Sensitivity Tests Polyenes biology.organism_classification Streptomyces P21 RAS Protein Anti-Bacterial Agents Drug Discovery Colonic Neoplasms Fermentation Tumor Cells Cultured Moiety Humans Actinomycetales Drug Screening Assays Antitumor Chirality (chemistry) Bacteria |
| Zdroj: | The Journal of antibiotics. 47(3) |
| ISSN: | 0021-8820 |
| Popis: | Three new manumycin class antibiotics, namely manumycins E, F and G, were isolated from the culture broth of Streptomyces sp. strain WB-8376. Their structures were established by spectroscopic methods, and the S configuration of C-4 in the epoxycyclohexenone moiety was determined by CD exciton chirality method for each of the three compounds. Manumycins E, F and G are active against Gram-positive bacteria, and have moderate inhibitory effects on the farnesylation of p21 ras protein. They demonstrated weak cytotoxic activity against human colon tumor cell HCT-116. |
| Databáze: | OpenAIRE |
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