Therapeutic apheresis in peripheral and retinal circulatory disorders
| Autor: | Alfonso Ramunni, Loreto Gesualdo, Giovanni Piscopo, Paola Brescia, Giuseppina De Fino |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Time Factors Rheopheresis Blood viscosity Article Microcirculation Peripheral Arterial Disease Retinal Diseases Structural Biology Internal medicine Humans Medicine LDL apheresis Optic Neuropathy Ischemic Radiology Nuclear Medicine and imaging Vascular Diseases Molecular Biology Angiology business.industry Microcirculation disorders Cholesterol LDL General Medicine Blood Viscosity Apheresis Immunology Circulatory system Blood Component Removal Cardiology business Lipoprotein |
| Zdroj: | Clinical Research in Cardiology Supplements |
| ISSN: | 1861-0714 1861-0706 |
| DOI: | 10.1007/s11789-012-0045-7 |
| Popis: | In microcirculation disorders, the therapeutic apheresis seems to have two different effects. The first, achieved after only a few sessions, is acute, consisting of drastic reduction of blood viscosity and obtained with the use of low-density lipoprotein (LDL) apheresis, rheopheresis, or fibrinogen apheresis. The second effect is long term, or chronic, and needs to be evaluated after a long course of treatment. The mechanisms underlying the chronic effect are still objects of debate and take into account the pleiotropic effects of apheresis. However, it is likely that the acute effect of apheresis mainly influences the functional components of the vascular damage, and so the derived rheological benefit might last only for a short period. The chronic effect, on the contrary, by acting on the morphological alterations of the vascular walls, requires the apheresis treatment to be prolonged for a longer period or even cycles of treatment to be programmed. |
| Databáze: | OpenAIRE |
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