Association of Thr12Ser polymorphism in mitochondrial transcription factor A TFAM gene with coronary artery disease

Autor:	V. M. Shipulin, I. V. Tsimbalyuk, O. A. Makeeva, A. A. Lezhnev, S. V. Buikin, V. P. Puzyryov, M. V. Golubenko, T. V. Zheikova
Rok vydání:	2012
Předmět:	Genetics Coronary artery disease medicine oxidative stress Medicine Molecular Medicine TFAM Biology medicine.disease Gene coronary artery disease mitochondrial transcription factor a
Zdroj:	Web of Science Bûlleten' Sibirskoj Mediciny, Vol 11, Iss 6, Pp 47-50 (2012)
ISSN:	1819-3684 1682-0363
Popis:	In this study we genotyped polymorphism Thr12Ser (rs1937) in TFAM gene in two groups: patients with coronary artery disease and control group (people from Tomsk population). For genotyping was used restriction fragment length polymorphism. We have found significant higher genotype CC frequency in men with coronary artery disease — 4.52% compared with control men — 0.45% (χ2 = 6.315; р = 0.043; OR = 10.45). Thus genotype CC is associated with coronary artery disease in men fromTomsk population.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba8d1979775b32984d7c2a4004038e29 https://doi.org/10.20538/1682-0363-2012-6-47-50 Zobrazit plný text záznamu