High Prevalence of bla CTX-M-1 /IncI1/ST3 and bla CMY-2 /IncI1/ST2 Plasmids in Healthy Urban Dogs in France
| Autor: | Estelle Saras, Marisa Haenni, Jean-Yves Madec, Véronique Métayer, Christine Médaille |
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| Rok vydání: | 2014 |
| Předmět: |
China
Paris Klebsiella pneumoniae Microbial Sensitivity Tests medicine.disease_cause beta-Lactamases Epidemiology and Surveillance Microbiology Dogs Plasmid Bacterial Proteins Escherichia coli Prevalence medicine Animals Humans Pharmacology (medical) Potential source Escherichia coli Infections Cephalosporinase Pharmacology High prevalence biology Salmonella enterica bacterial infections and mycoses biology.organism_classification Infectious Diseases Carriage Prevalence studies Plasmids |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 58:5358-5362 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.02545-14 |
| Popis: | In the community, close contacts between humans and dogs may promote the transfer of extended-spectrum beta-lactamase/plasmidic AmpC cephalosporinase (ESBL/pAmpC) genes. Large-scale prevalence studies on ESBL/pAmpC carriage in dogs are rare, and data on ESBL/pAmpC plasmids are even more limited. Here, a considerable rate of 18.5% ESBL/pAmpC carriers was found among 368 unrelated healthy dogs in Paris, France. This prevalence is much higher than the one found in healthy humans in the same city (6%) but close to that recently reported in dogs in China (24.5%). All isolates were identified as Escherichia coli , except one Salmonella enterica and one Klebsiella pneumoniae isolate. The sequence type 131 (ST131) clone was rare (2/73 isolates). Interestingly, two plasmids ( bla CTX-M-1 /IncI1/ST3 and bla CMY-2 /IncI1/ST2) were unexpectedly highly predominant, raising the question of their successful spread. Considering that CTX-M-1 was recently found to be equally as abundant as CTX-M-15 in healthy Parisian subjects, the question of dogs being a CTX-M-1 reservoir for humans is open. Such a high prevalence of the bla CMY-2 /IncI1/ST2 plasmid may result from the use of cephalexin in veterinary medicine, as previously demonstrated experimentally. In all, our study points out healthy urban dogs as a potential source of ESBL/pAmpC genes that can further disseminate to the human community. |
| Databáze: | OpenAIRE |
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