Metal-catalysed radical cyclisations leading to N-heterocycles: new approaches to gabapentin and pulchellalactam
| Autor: | Justin Stephen Bryans, Andrew F. Parsons, Nathalie Huther, Nicola E. A. Chessum, Franco Ghelfi |
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| Rok vydání: | 2003 |
| Předmět: |
chemistry.chemical_classification
Natural product amino acids cyclisations nitrogen heterocycles radical reactions Organic Chemistry chemistry.chemical_element Biological activity Pulchellalactam Biochemistry Copper Combinatorial chemistry Amino acid Ruthenium Metal chemistry.chemical_compound chemistry visual_art Drug Discovery visual_art.visual_art_medium Pyrrolidinones |
| Zdroj: | Tetrahedron. 59:6221-6231 |
| ISSN: | 0040-4020 |
| DOI: | 10.1016/s0040-4020(03)01030-5 |
| Popis: | The copper(I) or ruthenium(II)-mediated radical cyclisation of halo-amides has been utilised to afford functionalised pyrrolidinones via 5-endo-trig or 5-exo-trig radical cyclisation pathways. This methodology has been applied to novel and concise syntheses of the anti-epileptic drug gabapentin and the biologically active natural product pulchellalactam. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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