Association of Serotonin Transporter Promoter Polymorphism (5-HTTLPR) with Microscopic Colitis and Ulcerative Colitis
| Autor: | Satya Vati Rana, Saroj K. Sinha, Arbab Sikander, Kaushal K Prasad |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Serotonin medicine.medical_specialty Adolescent Physiology Gastroenterology Article Young Adult Sex Factors Microscopic colitis Polymorphism (computer science) Internal medicine Genotype Humans Medicine Prospective Studies Colitis Promoter Regions Genetic Serotonin transporter Aged Aged 80 and over Serotonin Plasma Membrane Transport Proteins Polymorphism Genetic biology business.industry Middle Aged medicine.disease Ulcerative colitis Colitis Microscopic Case-Control Studies 5-HTTLPR biology.protein Colitis Ulcerative Female Gene polymorphism business |
| Zdroj: | Digestive Diseases and Sciences. 60:887-894 |
| ISSN: | 1573-2568 0163-2116 |
| Popis: | Serotonin (5-HT) release and serotonin reuptake transporter (5-HTT) expression have been reported to be decreased in experimental colitis, in interleukin-10 knockout-associated colitis, and in patients with ulcerative colitis. Serotonin is known to play an important role in the pathogenesis of colitis, but individual genetic variants of 5-HTT gene in microscopic colitis and ulcerative colitis are not known. This study aimed to evaluate the association between the serotonin transporter gene promoter polymorphism (5-HTTLPR) and 5-HT concentration in microscopic colitis (MC) and ulcerative colitis (UC) patients. This prospective case–control study included 41 patients with microscopic colitis (age 19–82 years, mean 35 ± 13.6), 75 patients with ulcerative colitis (age 16–65 years, mean 38.5 ± 11.6), and 100 controls (age 20–64 years, mean 38 ± 11). 5-HTTLPR gene polymorphism was studied by polymerase chain reaction-based assay. 5-HT levels were measured by ELISA. The frequency of the 5-HTTLPR (SS) genotype was significantly lower in MC (12 %) patients compared to controls (30 %) (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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