Neural correlates of taste reactivity in autism spectrum disorder
| Autor: | Alex Martin, Sophie Wohltjen, Jason A. Avery, John E. Ingeholm, Meghan A. Collins, W. Kyle Simmons, Lauren Kenworthy, Cameron D. Riddell, Stephen J. Gotts, Gregory L. Wallace |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Taste medicine.medical_specialty Adolescent Autism Spectrum Disorder Autism Cognitive Neuroscience Insula Sensory system Audiology lcsh:Computer applications to medicine. Medical informatics Insular cortex behavioral disciplines and activities lcsh:RC346-429 Young Adult 03 medical and health sciences 0302 clinical medicine mental disorders medicine Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging lcsh:Neurology. Diseases of the nervous system Behavior Brain Mapping Resting state fMRI medicine.diagnostic_test business.industry fMRI 05 social sciences Brain Regular Article medicine.disease Magnetic Resonance Imaging Superior temporal sulcus Neurology Food Autism spectrum disorder lcsh:R858-859.7 Neurology (clinical) Nerve Net Gustatory cortex Functional magnetic resonance imaging business 030217 neurology & neurosurgery 050104 developmental & child psychology |
| Zdroj: | NeuroImage : Clinical NeuroImage: Clinical, Vol 19, Iss, Pp 38-46 (2018) |
| ISSN: | 2213-1582 |
| DOI: | 10.1016/j.nicl.2018.04.008 |
| Popis: | Selective or ‘picky’ eating habits are common among those with autism spectrum disorder (ASD). These behaviors are often related to aberrant sensory experience in individuals with ASD, including heightened reactivity to food taste and texture. However, very little is known about the neural mechanisms that underlie taste reactivity in ASD. In the present study, food-related neural responses were evaluated in 21 young adult and adolescent males diagnosed with ASD without intellectual disability, and 21 typically-developing (TD) controls. Taste reactivity was assessed using the Adolescent/Adult Sensory Profile, a clinical self-report measure. Functional magnetic resonance imaging was used to evaluate hemodynamic responses to sweet (vs. neutral) tastants and food pictures. Subjects also underwent resting-state functional connectivity scans. The ASD and TD individuals did not differ in their hemodynamic response to gustatory stimuli. However, the ASD subjects, but not the controls, exhibited a positive association between self-reported taste reactivity and the response to sweet tastants within the insular cortex and multiple brain regions associated with gustatory perception and reward. There was a strong interaction between diagnostic group and taste reactivity on tastant response in brain regions associated with ASD pathophysiology, including the bilateral anterior superior temporal sulcus (STS). This interaction of diagnosis and taste reactivity was also observed in the resting state functional connectivity between the anterior STS and dorsal mid-insula (i.e., gustatory cortex). These results suggest that self-reported heightened taste reactivity in ASD is associated with heightened brain responses to food-related stimuli and atypical functional connectivity of primary gustatory cortex, which may predispose these individuals to maladaptive and unhealthy patterns of selective eating behavior. Trial registration (clinicaltrials.gov identifier) NCT01031407. Registered: December 14, 2009. Highlights • We explored behavioral reactivity to taste in autism spectrum disorder (ASD). • In ASD subjects, taste reactivity was related to the brain's response to tastants. • Taste reactivity predicted tastant response in gustatory and social brain regions. • Taste reactivity predicted connectivity between gustatory and social brain regions. |
| Databáze: | OpenAIRE |
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