Immunological status of chronically exposed persons with increased level of TCR mutations
| Autor: | E.A. Blinova, Ilya I. Dolgushin, A. A. Akleyev |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Chronic exposure Time Factors Receptors Antigen T-Cell Biophysics 030218 nuclear medicine & medical imaging Red bone marrow 03 medical and health sciences 0302 clinical medicine Immunological status Humans Medicine Individual dose Aged General Environmental Science Aged 80 and over Radiation business.industry T-cell receptor Immunity Dose-Response Relationship Radiation Middle Aged Radiation Exposure Peripheral blood 030220 oncology & carcinogenesis Mutation Immunology Female business |
| Zdroj: | Radiation and Environmental Biophysics. 58:81-88 |
| ISSN: | 1432-2099 0301-634X |
| DOI: | 10.1007/s00411-018-0766-1 |
| Popis: | Dose- and dose rate-dependent increase in the number of СD3+СD16+CD56+-lymphocytes and lysosomal activity of neutrophils was noted in peripheral blood of the Techa riverside residents with increased level of TCR gene-mutated T lymphocytes long after chronic exposure of predominantly red bone marrow (mean exposure dose was 0.89 ± 0.09 Gy, individual dose range was 0.09–1.96 Gy). The performed analysis showed that the above-mentioned immunological changes could be a response to an increase in the frequency of mutations (TCR mutations in particular) in the cells of exposed individuals. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink