Pediatric cardiovascular effects of imipramine and desipramine
| Autor: | Stanley J. Stamm, Christopher K. Varley, Mary G. Bartels, Jeff Mitchell |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Imipramine Adolescent medicine.drug_class Tricyclic antidepressant Pilot Projects Electrocardiography Double-Blind Method Desipramine Developmental and Educational Psychology medicine Humans PR interval Child Depressive Disorder medicine.diagnostic_test business.industry medicine.disease Anxiety Disorders Psychiatry and Mental health Heart Block El Niño Anesthesia Toxicity Female business Atrioventricular block medicine.drug |
| Zdroj: | Journal of the American Academy of Child and Adolescent Psychiatry. 30(1) |
| ISSN: | 0890-8567 |
| Popis: | Electrocardiograms were evaluated in 39 children and adolescents before and after the clinical use of imipramine and desipramine. The average increase in PR interval was 0.01 seconds. The PR interval increased by 0.02 seconds in 11 subjects, and a new first-degree atrioventricular block developed in two subjects. These changes were not related to the choice between imipramine and desipramine, the dose, or the method of administration. An increase in PR interval by 0.02 seconds or more did correlate with having an abnormality disclosed on a pretreatment electrocardiogram. The average increase in PR interval was 0.007 seconds for subjects with normal baseline electrocardiograms and 0.019 seconds for subjects with conduction and nonconduction abnormalities disclosed in baseline tracings. None of the electrocardiogram changes resulted in adverse clinical consequences. J. Am. Acad. Child Adolesc. Psychiatry , 1991, 30, 1:100–103. |
| Databáze: | OpenAIRE |
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