Pregnancy Outcomes in Systemic Lupus Erythematosus Women: A single tertiary centre experience
| Autor: | Nihal Al-Riyami, Batool Hassan, Amani Al-Rashdi, Bushra Salman, Rahma Al-Haddabi, Tamima Al-Dughaishi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Oman Lupus nephritis Clinical & Basic Research Intrauterine growth restriction Systemic Lupus Erythematosus Miscarriage Preeclampsia immune system diseases Antiphospholipid syndrome Pregnancy medicine Antiphospholipid Antibodies Humans Lupus Erythematosus Systemic skin and connective tissue diseases Retrospective Studies Eclampsia Obstetrics business.industry Cesarean Section Infant Newborn Pregnancy Outcome Gestational age Infant Prenatal Care General Medicine Pregnancy Outcomes medicine.disease Delivery Obstetric Symptom Flare Up Lupus Nephritis Neonatal Lupus Pregnancy Complications Antibodies Antiphospholipid Premature Birth Female business |
| Zdroj: | Sultan Qaboos University Medical Journal |
| ISSN: | 2075-0528 |
| Popis: | Objectives: This study was conducted to assess pregnancy outcomes in women with systemic lupus erythematosus (SLE) in Oman. Methods: A retrospective cohort study of 149 pregnancies in 98 women with SLE was conducted over 10 years to evaluate the impact of clinical and laboratory parameters in predicting adverse pregnancy outcomes. Results: Mean maternal age was 30.6 ± 5 years ranging from 20–44 years, and the mean disease duration was 10 ± 5 years, ranging from 2–27 years. The most common maternal manifestations were joint pain in 36 (24.2%), lupus nephritis (LN) in 18 (12.08%), preeclampsia in 11 (7.4%), eclampsia in three (2%) and lupus flare in one pregnancy. The live birth rate was 139 (93.3%) with a mean gestational age of 36 ± 2 weeks ranging from 26–40 weeks. In total, 55 (39.6%) were preterm deliveries, six (4%) pregnancies ended in miscarriage, and four (2.7%) resulted in intrauterine fetal death. Intrauterine growth restriction was observed in 49 babies (35%). A significant association was found between hypertension (HTN) and miscarriage (P = 0.024) and preterm birth (P = 0.019). In addition, HTN was positively associated with preeclampsia (P = 0.004) and LN (P = 0.048). Antiphospholipid syndrome impacted preterm birth (P = 0.013) and postpartem haemorrhage (PPH) (P = 0.027) and was found to be a significant predictor for women developing deep vein thrombosis and pulmonary embolism (P |
| Databáze: | OpenAIRE |
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