Impact on parents of HLA-DQ2/DQ8 genotyping in healthy children from coeliac families
| Autor: | Wessels, M.M.S., Vriezinga, S.L., Koletzko, S., Werkstetter, K., Castillejo-De Villasante, G., Shamir, R., Hartman, C., Putter, H., Pal, S.M. van der, Wijmenga, C., Bravi, E., Mearin, M.L., PreventCD Study Grp |
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| Přispěvatelé: | Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Health Knowledge Attitudes Practice Genotype STRATEGIES media_common.quotation_subject HETERODIMER MEDLINE Short Report Disease Affect (psychology) Coeliac disease Quality of life (healthcare) DISEASE PATIENTS QUALITY-OF-LIFE HLA-DQ Antigens Surveys and Questionnaires Genetics medicine Humans Family Genetic Predisposition to Disease ATTITUDES Child Genetics (clinical) media_common RISK business.industry Histocompatibility Testing HLA-DQ2 Infant nutritional and metabolic diseases medicine.disease Distress Celiac Disease Feeling Family medicine Child Preschool Female business |
| Zdroj: | European Journal of Human Genetics, 23(3), 405-408 European Journal of Human Genetics, 23(3), 405-408. Nature Publishing Group |
| ISSN: | 1018-4813 |
| Popis: | Due to the association of coeliac disease and HLA-specificities DQ2 and DQ8, HLA-typing can be used for risk determination of the disease. This study was designed to evaluate the knowledge of parents from coeliac families regarding HLA-typing and the impact of HLA-typing on the perception of the health of their children. A structured questionnaire was sent to the Dutch, Spanish and German parents participating with their child in the European PreventCD study on disease prevention in high-risk families, addressing parents' understanding of and attitude towards HLA-typing, distress related to HLA-typing and perceived health and health-related quality of life of their children. Sixty-eight percent of parents of 515 children returned the questionnaires, with 85% of children being DQ2/DQ8 positive. The majority of all parents answered the questions on knowledge correctly. Forty-eight percent of parents of DQ2/DQ8-negative children thought their child could develop coeliac disease. More distress was reported by parents of DQ2/DQ8-positive children (P |
| Databáze: | OpenAIRE |
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