Integrated genomic surveillance enables tracing of person-to-person SARS-CoV-2 transmission chains during community transmission and reveals extensive onward transmission of travel-imported infections, Germany, June to July 2021
| Autor: | Torsten, Houwaart, Samir, Belhaj, Emran, Tawalbeh, Dirk, Nagels, Yara, Fröhlich, Patrick, Finzer, Pilar, Ciruela, Aurora, Sabrià, Mercè, Herrero, Cristina, Andrés, Andrés, Antón, Assia, Benmoumene, Dounia, Asskali, Hussein, Haidar, Janina, von Dahlen, Jessica, Nicolai, Mygg, Stiller, Jacqueline, Blum, Christian, Lange, Carla, Adelmann, Britta, Schroer, Ute, Osmers, Christiane, Grice, Phillipp P, Kirfel, Hassan, Jomaa, Daniel, Strelow, Lisanna, Hülse, Moritz, Pigulla, Pascal, Kreuzer, Alona, Tyshaieva, Jonas, Weber, Tobias, Wienemann, Malte, Kohns Vasconcelos, Katrin, Hoffmann, Nadine, Lübke, Sandra, Hauka, Marcel, Andree, Claus Jürgen, Scholz, Nathalie, Jazmati, Klaus, Göbels, Rainer, Zotz, Klaus, Pfeffer, Jörg, Timm, Lutz, Ehlkes, Andreas, Walker, Alexander T, Dilthey, John, Ziebuhr |
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| Přispěvatelé: | Institut Català de la Salut, [Houwaart T] Institute of Medical Microbiology and Hospital Hygiene, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. [Belhaj S, Tawalbeh E, Nagels D] Düsseldorf Health Authority (Gesundheitsamt Düsseldorf), Düsseldorf, Germany. [Fröhlich Y] Institute of Virology, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. [Finzer P] Institute of Medical Microbiology and Hospital Hygiene, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. Zotz | Klimas, Düsseldorf, Germany. [Andrés C, Antón A] Unitat de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Travel
Natural Science Disciplines::Biological Science Disciplines::Biology::Computational Biology::Genomics [DISCIPLINES AND OCCUPATIONS] SARS-CoV-2 Epidemiology técnicas de investigación::métodos epidemiológicos::rastreo de contactos [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS] Public Health Environmental and Occupational Health COVID-19 Bacterial Infections and Mycoses::Infection::Communicable Diseases::Communicable Diseases Imported [DISEASES] Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES] infecciones bacterianas y micosis::infección::enfermedades transmisibles::enfermedades transmisibles importadas [ENFERMEDADES] Genomics Genòmica Communicable Diseases Imported Germany Virology disciplinas de las ciencias naturales::disciplinas de las ciencias biológicas::biología::biología computacional::genómica [DISCIPLINAS Y OCUPACIONES] COVID-19 (Malaltia) - Transmissió Investigative Techniques::Epidemiologic Methods::Contact Tracing [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT] virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES] Humans Malalties transmissibles Contact Tracing Phylogeny |
| Zdroj: | Scientia |
| Popis: | Background Tracking person-to-person SARS-CoV-2 transmission in the population is important to understand the epidemiology of community transmission and may contribute to the containment of SARS-CoV-2. Neither contact tracing nor genomic surveillance alone, however, are typically sufficient to achieve this objective. Aim We demonstrate the successful application of the integrated genomic surveillance (IGS) system of the German city of Düsseldorf for tracing SARS-CoV-2 transmission chains in the population as well as detecting and investigating travel-associated SARS-CoV-2 infection clusters. Methods Genomic surveillance, phylogenetic analysis, and structured case interviews were integrated to elucidate two genetically defined clusters of SARS-CoV-2 isolates detected by IGS in Düsseldorf in July 2021. Results Cluster 1 (n = 67 Düsseldorf cases) and Cluster 2 (n = 36) were detected in a surveillance dataset of 518 high-quality SARS-CoV-2 genomes from Düsseldorf (53% of total cases, sampled mid-June to July 2021). Cluster 1 could be traced back to a complex pattern of transmission in nightlife venues following a putative importation by a SARS-CoV-2-infected return traveller (IP) in late June; 28 SARS-CoV-2 cases could be epidemiologically directly linked to IP. Supported by viral genome data from Spain, Cluster 2 was shown to represent multiple independent introduction events of a viral strain circulating in Catalonia and other European countries, followed by diffuse community transmission in Düsseldorf. Conclusion IGS enabled high-resolution tracing of SARS-CoV-2 transmission in an internationally connected city during community transmission and provided infection chain-level evidence of the downstream propagation of travel-imported SARS-CoV-2 cases. |
| Databáze: | OpenAIRE |
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