Evaluation of the Dose-Dependent Effects of Fermented Mixed Grain Enzyme Food on Adiposity and Its Metabolic Disorders in High-Fat Diet-Induced Obese Mice
| Autor: | Ae-Hyang Kim, Eun-Young Kwon, Myung-Sook Choi, Youngji Han, Young Chul Shin |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Normal diet Medicine (miscellaneous) Mice Obese Diet High-Fat Proinflammatory cytokine Mice Metabolic Diseases Weight loss Internal medicine medicine Animals Obesity Adiposity chemistry.chemical_classification Nutrition and Dietetics biology business.industry Body Weight food and beverages medicine.disease Mice Inbred C57BL Endocrinology Enzyme Nutrigenomics chemistry Digestive enzyme biology.protein Metabolic syndrome medicine.symptom business |
| Zdroj: | Journal of medicinal food. 24(8) |
| ISSN: | 1557-7600 |
| Popis: | Ancient traditions showed that fermented enzyme foods have beneficial health effects on the body. However, only a few studies have reported on its impact on weight loss and metabolic syndrome. Therefore, it is necessary to verify whether diet supplementation with fermented enzyme foods can have a beneficial functional impact on the body. We examined the antiobesity properties of fermented mixed grain (FMG) with digestive enzymes (FMG) in diet-induced obese mice. Sixty C57BL/6J mice were randomly assigned to six dietary groups: (1) normal diet (ND), (2) high-fat diet (HFD), (3) Bacilus Coagulans, (4) steamed grain, (5) low-dose FMG (L-FMG), and (6) high-dose FMG (H-FMG) supplement for 12 weeks. The results showed that H-FMG supplement dramatically decreased body weight and fat mass with simultaneous decreases in plasma lipid contents. Furthermore, H-FMG significantly lowered fasting blood glucose concentrations and improved glucose tolerance compared with the HFD group. Also, the concentrations of inflammatory cytokines secreted from adipocytes in H-FMG-supplemented mice decreased dramatically. Taken together, our findings indicated that H-FMG can ameliorate HFD-induced obesity and its associated complications and could be used as a potential preventive intervention for obesity. |
| Databáze: | OpenAIRE |
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