Continuous and Prolonged Intravenous β-Lactam Dosing: Implications for the Clinical Laboratory
| Autor: | David P. Nicolau, Joseph L. Kuti, Mordechai Grupper |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty Epidemiology medicine.drug_class 030106 microbiology Antibiotics Treatment outcome Reviews beta-Lactams Beta-lactam 03 medical and health sciences chemistry.chemical_compound Humans Medicine Dosing Infusions Intravenous Intensive care medicine Bacteria General Immunology and Microbiology Low toxicity business.industry Public Health Environmental and Occupational Health Bacterial Infections Anti-Bacterial Agents Treatment Outcome Infectious Diseases chemistry business |
| Zdroj: | Clinical Microbiology Reviews. 29:759-772 |
| ISSN: | 1098-6618 0893-8512 |
| Popis: | SUMMARY Beta-lactam antibiotics serve as a cornerstone in the management of bacterial infections because of their wide spectrum of activity and low toxicity. Since resistance rates among bacteria are continuously on the rise and the pipeline for new antibiotics does not meet this trend, an optimization of current beta-lactam treatment is needed. This review provides an overview of optimization through use of prolonged- and continuous-infusion dosing strategies compared with more traditional intermittent infusions. Included is an overview of the scientific basis for using these nontraditional prolonged- and continuous-infusion-based regimens, with a focus on major areas in which the clinical laboratory can support the clinical use of these regimens. |
| Databáze: | OpenAIRE |
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