Dynamic Changes of Mitochondrial DNA Copy Number in Gastrointestinal Tract Cancers: A Systematic Review and Meta-Analysis
| Autor: | Sana Eybpoosh, Eliette Touati, Mehdi Alikhani, Morteza Karimipoor, Massoud Vosough, Marjan Mohammadi |
|---|---|
| Přispěvatelé: | Institut Pasteur d'Iran, Réseau International des Instituts Pasteur (RIIP), Pathogenèse de Helicobacter / Helicobacter Pathogenesis, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Academic Center for Education, Culture and Research (ACECR), This study was carried out in partial fulfillment of MA PhD dissertation (code: TP-9347) at Pasteur Institute of Iran and was supported by IPI grant [number 833]. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Mitochondrial DNA tumor DNA Copy Number Variations mtDNA copy number MESH: Mitochondria [SDV.CAN]Life Sciences [q-bio]/Cancer DNA Mitochondrial Mean difference systematic review and meta-analysis 03 medical and health sciences MESH: Gastrointestinal Neoplasms 0302 clinical medicine systematic review Internal medicine PBL medicine Humans MESH: Early Detection of Cancer Genetic Predisposition to Disease Early Detection of Cancer Gastrointestinal Neoplasms Gastrointestinal Tract Cancers Gastrointestinal tract MESH: Humans business.industry MESH: DNA Mitochondrial MESH: Genetic Predisposition to Disease gastrointestinal tract cancers General Medicine Tumor tissue Peripheral blood Mitochondria MESH: Leukocytes Mononuclear 030104 developmental biology 030220 oncology & carcinogenesis Meta-analysis Leukocytes Mononuclear MESH: DNA Copy Number Variations Cancer development business |
| Zdroj: | Cancer Investigation Cancer Investigation, 2021, 39 (2), pp.1-20. ⟨10.1080/07357907.2020.1857394⟩ |
| ISSN: | 0735-7907 1532-4192 |
| DOI: | 10.1080/07357907.2020.1857394⟩ |
| Popis: | International audience; We have performed a systematic review and meta-analysis for evaluation of mitochondrial DNA copy number (mtDNA-CN) alterations in peripheral blood leukocytes (PBL), and tumor tissues of gastrointestinal tract (GIT) cancers. Analysis of the PBL demonstrated a significant decrease [OR: 0.6 (0.5, 0.8)] and increase [OR: 1.4 (1.1, 1.9)] prior to and following GIT cancer development, respectively. This trend was more evident in CRC, and GC subgroups. Analysis of tissue yielded high levels of heterogeneity. However, the mean difference for the CRC subgroup was statistically significant [1.5 (1.0, 2.2)]. Our analysis suggests mtDNA-CN deserves further investigations as a GIT-cancer screening tool. |
| Databáze: | OpenAIRE |
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