The Role of Immunosuppressive Medications in the Pathogenesis of Hypertension and Efficacy and Safety of Antihypertensive Agents in Kidney Transplant Recipients
| Autor: | Nevena Divac, Radomir Naumović, Radan Stojanović, Milica Prostran |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Graft Rejection
medicine.medical_specialty Renal function Angiotensin-Converting Enzyme Inhibitors 030204 cardiovascular system & hematology Pharmacology 030226 pharmacology & pharmacy Biochemistry Gastroenterology 03 medical and health sciences 0302 clinical medicine Adrenal Cortex Hormones Risk Factors Internal medicine Drug Discovery medicine Humans Diuretics Antihypertensive Agents Kidney transplantation Thiazide business.industry Calcineurin Organic Chemistry Calcium Channel Blockers medicine.disease Kidney Transplantation 3. Good health Blood pressure Tolerability Sirolimus Hypertension Molecular Medicine business Immunosuppressive Agents Kidney disease medicine.drug |
| Zdroj: | Current Medicinal Chemistry. 23:1941-1952 |
| ISSN: | 0929-8673 |
| DOI: | 10.2174/0929867323666151221150052 |
| Popis: | The purpose of this review is to summarize current data on the role of immunosuppressants in the pathogenesis of hypertension and the efficacy and tolerability of major antihypertensive classes in kidney transplant recipients. Arterial hypertension is a common complication after kidney transplantation and a major risk factor for adverse outcome and graft rejection due to blood pressure elevation by immunosuppressive medications. Calcineurin inhibitors induce hypertension by a mechanism related to the imbalance of vasoactive substances endothelin and nitric oxide, and probably by causing overactivity of thiazide-sensitive sodium-chloride-cotransporter. Corticosteroids are well known for their hypertensive effects. The interactions of calcineurin inhibitors and mammalian target of rapamycin inhibitor sirolimus also promote hypertension. Management of arterial hypertension is a complex problem in the care of kidney transplant recipients. Target blood pressure values of |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|