Intratympanic Dexamethasone Injection for Refractory Sudden Sensorineural Hearing Loss
| Autor: | Min Jung Cho, Yun-Hoon Choung, You Ree Shin, Keehyun Park |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Tympanic Membrane Supine position medicine.drug_class Hearing Loss Sensorineural Anti-Inflammatory Agents Drug Resistance Administration Oral Intratympanic dexamethasone Injections Intralesional Risk Assessment Severity of Illness Index Dexamethasone Drug Administration Schedule Adrenal Cortex Hormones otorhinolaryngologic diseases Humans Hearing improvement Medicine Probability Retrospective Studies Dose-Response Relationship Drug business.industry Tympan Hearing Loss Sudden Surgery Regimen Treatment Outcome Otorhinolaryngology Case-Control Studies Sudden sensorineural hearing loss Audiometry Pure-Tone Corticosteroid Female business Follow-Up Studies medicine.drug |
| Zdroj: | The Laryngoscope. 116:747-752 |
| ISSN: | 0023-852X |
| DOI: | 10.1097/01.mlg.0000205183.29986.f6 |
| Popis: | Objective: This case-control study aimed to analyze the effect of intratympanic dexamethasone injection (ITDI) as a treatment option for patients with sudden sensorineural hearing loss (SSNHL) who were refractory to classic oral steroid treatment. Methods: Sixty-six patients with SSNHL, who were refractory to a course of oral steroid therapy, were included in this study. We prospectively treated consecutive 33 patients (34 ears) with ITDI from August 2002 to January 2004. We then retrospectively collected data from age- and sex-matched previous patients who did not take any more treatments after the initial regimen between March 2000 and July 2002. ITDI was performed in the supine position on four separate occasions over the course of 2 weeks. Hearing was assessed immediately before every injection and at 1 week after therapy. Hearing improvement was defined as more than 10 dB in pure-tone average (PTA). Results: Hearing improvement was observed in 13 (39.4%) of 33 patients who underwent ITDI and in two (6.1%) of 33 patients in the control group. Five of 13 represented hearing improvement over than 20 dB in PTA, and 11 of 20 patients, who showed no improvement in PTA by ITDI, showed improvement over 10 dB in some frequencies. There were no definite prognostic factors between the patients who responded to ITDI and those who did not. Conclusion: ITDI may be a simple and effective therapy for patients with refractory SSNHL. |
| Databáze: | OpenAIRE |
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