Multi-vessel coronary artery aneurysms in a patient with Parry Romberg syndrome: a case report
| Autor: | Michael Berlowitz, Jaymin Patel, Andrew Mehlman, Christopher Bitetzakis |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Disease Case Reports 030204 cardiovascular system & hematology Chest pain 03 medical and health sciences 0302 clinical medicine Histopathological studies Ectasia Internal medicine Case report Medicine cardiovascular diseases Parry Romberg syndrome Intravascular inflammation biology business.industry Parry–Romberg syndrome 030206 dentistry Coronary artery aneurysms medicine.disease Troponin Statin therapy Coronary arteries medicine.anatomical_structure Cardiology biology.protein medicine.symptom Cardiology and Cardiovascular Medicine business Rare disease Artery |
| Zdroj: | European Heart Journal: Case Reports |
| ISSN: | 2514-2119 |
| Popis: | BackgroundCoronary artery aneurysms (CAAs) are a very rare finding on coronary angiograms with multiple known aetiologies. Parry Romberg syndrome (PRS) is also a very rare disease, and the underlying aetiology remains unknown. We present a rare case of CAAs in a patient with PRS, and discuss possible implications regarding the primary pathophysiological cause for both of these diseases.Case summaryA 48-year-old woman with a history of PRS presented with atypical and non-exertional chest pain. Initial evaluation demonstrated a rising troponin without associated electrocardiogram changes, and as such she was taken for left heart catheterization. Left heart catheterization demonstrated diffuse aneurysmal and ectatic disease of multiple coronary arteries. Further evaluation with magnetic resonance angiogram and autoantibody panel did not demonstrate other vascular anomalies or rheumatologic disease, respectively. She was treated with dual anti-platelet therapy and statin, and at 1 year follow-up, she had resolution of her symptoms.DiscussionIt has been postulated that the underlying mechanism causing CAA is intravascular inflammation. Parry Romberg syndrome is theorized to be a neurovasculopathy, as evidenced by cases of associated intracranial aneurysms. Intravascular inflammation may play a key pathological role in CAA, and an association between CAA and PRS may exist. |
| Databáze: | OpenAIRE |
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