Impact of arsenic exposure on clinical biomarkers indicative of cardiovascular disease risk in Mexican women

Autor: Tania Ruíz-Vera, Ángeles C. Ochoa-Martínez, Claudia I. Almendarez-Reyna, Sergio Zarazúa, Leticia Carrizales-Yáñez, Iván N. Pérez-Maldonado
Rok vydání: 2019
Předmět:
Adult
Male
medicine.medical_specialty
Health
Toxicology and Mutagenesis
Urinary system
0211 other engineering and technologies
02 engineering and technology
010501 environmental sciences
Arginine
Fatty Acid-Binding Proteins
01 natural sciences
Gastroenterology
Arsenic
chemistry.chemical_compound
Predictive Value of Tests
Risk Factors
Surveys and Questionnaires
Adipocyte
Internal medicine
Humans
Medicine
Chemerin
Mexico
Aged
0105 earth and related environmental sciences
021110 strategic
defence & security studies
Creatinine
Framingham Risk Score
Adiponectin
biology
business.industry
Drinking Water
Public Health
Environmental and Occupational Health
Environmental Exposure
General Medicine
Middle Aged
Pollution
Cross-Sectional Studies
chemistry
Cardiovascular Diseases
Multivariate Analysis
biology.protein
Biomarker (medicine)
Female
business
Asymmetric dimethylarginine
Biomarkers
Water Pollutants
Chemical
Zdroj: Ecotoxicology and Environmental Safety. 169:678-686
ISSN: 0147-6513
DOI: 10.1016/j.ecoenv.2018.11.088
Popis: An appropriate and precise identification of high-risk individuals to develop cardiovascular diseases (CVD) is of high importance to reduce these kinds of diseases, a major health concern worldwide. Therefore, the aim of this research was to evaluate prognostic CVD biomarkers in Mexican women exposed to inorganic arsenic via drinking water. Then, a cross-sectional study including 190 women was achieved. Urinary arsenic (UAs) levels were analyzed as exposure biomarker to that metalloid. While, plasma asymmetric dimethylarginine (ADMA), adipocyte fatty acid-binding protein (FABP4), adiponectin, and chemerin levels, hypertriglyceridemic waist (HW) phenotype, atherogenic index of plasma (AIP), and Framingham risk score (FRS) were assessed as prognostic CVD biomarkers. Mean UAs level detected in the evaluated urinary samples was 45.0 ± 40.0 μg/g creatinine. In addition, mean plasma ADMA, FABP4, chemerin and adiponectin levels were 0.68 µmol/L, 20.3 ng/mL, 12.5 μg/mL, and 255 ng/mL, correspondingly. Approximately, 54% of women participants displayed an HW phenotype. Regarding AIP and FRS values, 0.12 ± 0.15 and 7.50 ± 8.00 were found, respectively. Besides, strong and significant associations (p 0.05) between UAs and AIP, ADMA, and FABP4 were distinguished. Also, after a multivariate analysis, the association between those variables persisted after adjustment for traditional risk factors of CVD. In conclusion, according to the results found in this research, the most sensible CVD biomarkers distinguished in this study were AIP, ADMA, and FABP4. Nevertheless, more studies are necessary to confirm the results found in this investigation.
Databáze: OpenAIRE
Externí odkaz: