Actinomycotic Osteomyelitis of the Mandible Diagnosed Using Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry: A Case Report
| Autor: | Naoki Taniike, Shinsuke Yamamoto, Toshihiko Takenobu, Hiroshi Takegawa |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Minocycline Matrix assisted laser desorption ionization time of flight Trismus Actinomycosis 03 medical and health sciences 0302 clinical medicine Actinomyces oris Humans Medicine Mandibular Diseases Aged 80 and over Genus Actinomyces business.industry Osteomyelitis Mandible 030206 dentistry medicine.disease Magnetic Resonance Imaging Anti-Bacterial Agents Treatment Outcome 030104 developmental biology Otorhinolaryngology Spectrometry Mass Matrix-Assisted Laser Desorption-Ionization Female Surgery Radiology Anaerobic bacteria Oral Surgery medicine.symptom Tomography X-Ray Computed business |
| Zdroj: | Journal of Oral and Maxillofacial Surgery. 76:2122-2130 |
| ISSN: | 0278-2391 |
| DOI: | 10.1016/j.joms.2018.04.020 |
| Popis: | Actinomycosis is a rare, chronic, slowly progressive granulomatous disease caused by filamentous gram-positive anaerobic bacteria from the Actinomycetaceae family (genus Actinomyces). It has become a rare condition because of the widespread use of antibiotics. When clinical symptoms are not typical, diagnosis of this condition becomes difficult. This report describes a case involving an 82-year-old woman who was diagnosed with actinomycotic osteomyelitis of the mandible using matrix assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS). The patient was referred to the authors' department with chief complaints of swelling, multiple fistulae in the left preauricular region, and trismus. The authors performed fine-needle aspiration microbiology (FNAM) and identified Actinomyces oris using MALDI-TOF MS. A diagnosis of actinomycotic osteomyelitis of the mandible was made and the patient was treated with minocycline and extraction of the culprit tooth. The findings from this case have 2 important implications. First, for patients with clinically suspected actinomycosis, bacteriologic examinations should include not only surface swab tests but also FNAM; moreover, communication with the laboratory medical technologist is important to improve detection of the causative organisms. Second, MALDI-TOF MS could be an effective tool for improving the diagnosis and treatment outcomes of actinomycosis. |
| Databáze: | OpenAIRE |
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