Degradable multi(aryl azide) star copolymer as universal photo-crosslinker for elastomeric scaffolds
| Autor: | Louis Gangolphe, Benjamin Nottelet, Sylvie Hunger, Stéphane Dejean, Frédéric Bossard, Audrey Bethry, Coline Pinese, Xavier Garric |
|---|---|
| Přispěvatelé: | Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Rhéologie et Procédés (LRP), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]) |
| Rok vydání: | 2019 |
| Předmět: |
Materials science
Polymers and Plastics 02 engineering and technology 010402 general chemistry Elastomer 01 natural sciences Catalysis Biomaterials chemistry.chemical_compound Colloid and Surface Chemistry Materials Chemistry Copolymer ComputingMilieux_MISCELLANEOUS chemistry.chemical_classification Lactide Aryl [CHIM.MATE]Chemical Sciences/Material chemistry Polymer 021001 nanoscience & nanotechnology 0104 chemical sciences Electronic Optical and Magnetic Materials chemistry Chemical engineering Azide 0210 nano-technology Ethylene glycol Macromolecule |
| Zdroj: | Materials Today Chemistry Materials Today Chemistry, Elsevier, 2019, 12, pp.209-221. ⟨10.1016/j.mtchem.2018.12.008⟩ |
| ISSN: | 2468-5194 |
| Popis: | Degradable elastomers with elastic properties close to those of soft tissues are necessary for tissue engineering. Most degradable elastomers developed so far are based on functional low–molecular-weight prepolymers that are combined with molecular crosslinkers to yield the elastomeric three-dimensional networks. To overcome this limitation, we present in this work the concept of star-shaped macromolecular multi(aryl azide) photo-crosslinker that has the ability to efficiently cross-link any polymer containing C-H bonds independently of its molecular weight and without the need for prefunctionalization. This concept of universal crosslinking agent is illustrated with a star-shaped block copolymer composed of an 8-arm poly(ethylene glycol) core and poly(lactide) side arms functionalized with aryl azide moieties (PEG8arm-PLA-fN3). It was selected due to its macromolecular nature that allows for an easy processing of electrospun photo-crosslinked scaffolds, while making it possible to adapt its chemical nature with one of the polymer matrices. A parameter study is first carried out on PEG8arm-PLA-fN3/PLA-Pluronic®-PLA films to evaluate the impact of the polymers' molecular weight, PEG/PLA ratios, and UV irradiation conditions on the crosslinking efficiency. This study confirms that high crosslinking efficiencies can be obtained with PEG8arm-PLA-fN3 (60%) compared with commercially available bis(aryl azide) photo-crosslinker (below 15%). Optimal conditions are then used to yield electrospun microfibers (1–2 μm) crosslinked with PEG8arm-PLA-fN3, resulting in biocompatible and highly elastomeric scaffolds ( e y > 100 % ) compared with uncrosslinked scaffolds ( e y 10 % ). In addition, we show that the degradation rate can be controlled overtime depending on the blend content of PEG8arm-PLA-fN3. Taken together, these results demonstrate the potential of macromolecular multi(aryl azide) photo-crosslinkers to develop original degradable elastomeric scaffolds for soft tissue reconstruction. |
| Databáze: | OpenAIRE |
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