Yoga and Cardiovascular Health Trial (YACHT): a UK-based randomised mechanistic study of a yoga intervention plus usual care versus usual care alone following an acute coronary event
Autor: | Naveed Sattar, Barbara Sowa, Paul Welsh, Shah Ebrahim, C Tuson, Therese Tillin, Nishi Chaturvedi, Sanjay Kinra, Alun D. Hughes, Kaushik Chattopadhyay, Ian Roberts |
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Rok vydání: | 2019 |
Předmět: |
Adult
Male medicine.medical_specialty Cardiovascular health medicine.medical_treatment Coronary Disease Cardiovascular Medicine 03 medical and health sciences 0302 clinical medicine Intervention (counseling) London Heart rate heart rate Humans Medicine 030212 general & internal medicine Aged Original Research Aged 80 and over Cardiac Rehabilitation Rehabilitation Coronary event exercise business.industry Yoga blood pressure General Medicine Middle Aged humanities 3. Good health Test (assessment) Treatment Outcome Blood pressure Acute Disease Usual care Physical therapy Female business human activities 030217 neurology & neurosurgery |
Zdroj: | BMJ Open |
ISSN: | 2044-6055 |
DOI: | 10.1136/bmjopen-2019-030119 |
Popis: | ObjectiveTo determine the effects of yoga practice on subclinical cardiovascular measures, risk factors and neuro-endocrine pathways in patients undergoing cardiac rehabilitation (CR) following acute coronary events.Design3-month, two-arm (yoga +usual care vs usual care alone) parallel randomised mechanistic study.SettingOne general hospital and two primary care CR centres in London. Assessments were conducted at Imperial College London.Participants80 participants, aged 35–80 years (68% men, 60% South Asian) referred to CR programmes 2012–2014.InterventionA certified yoga teacher conducted yoga classes which included exercises in stretching, breathing, healing imagery and deep relaxation. It was pre-specified that at least 18 yoga classes were attended for inclusion in analysis. Participants and partners in both groups were invited to attend weekly a 6- to 12-week local standard UK National Health Service CR programme.Main outcome measures(i) Estimated left ventricular filling pressure (E/e′), (ii) distance walked, fatigue and breathlessness in a 6 min walk test, (iii) blood pressure, heart rate and estimated peak VO2 following a 3 min step-test. Effects on the hypothalamus–pituitary–adrenal axis, autonomic function, body fat, blood lipids and glucose, stress and general health were also explored.Results25 participants in the yoga + usual care group and 35 participants in the usual care group completed the study. Following the 3-month intervention period, E/e′ was not improved by yoga (E/e′: between-group difference: yoga minus usual care:−0.40 (−1.38, 0.58). Exercise testing and secondary outcomes also showed no benefits of yoga.ConclusionsIn this small UK-based randomised mechanistic study, with 60 completing participants (of whom 25 were in the yoga + usual care group), we found no discernible improvement associated with the addition of a structured 3-month yoga intervention to usual CR care in key cardiovascular and neuroendocrine measures shown to be responsive to yoga in previous mechanistic studies.Trial registration numberNCT01597960; Pre-results. |
Databáze: | OpenAIRE |
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