Early Prognostic Value of Monitoring Serum Free Light Chain in Patients with Multiple Myeloma Undergoing Autologous Stem Cell Transplantation
| Autor: | Rauf Haznedar, Zübeyde Nur Özkurt, Gülsan Türköz Sucak, Münci Yağcı, Şahika Zeynep Akı |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Kaplan-Meier Estimate Immunoglobulin light chain Transplantation Autologous Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Autologous stem-cell transplantation Serum free Internal medicine Biomarkers Tumor medicine Humans Progression-free survival Multiple myeloma Aged Retrospective Studies business.industry Hematopoietic Stem Cell Transplantation General Medicine Middle Aged Prognosis medicine.disease Combined Modality Therapy Free Light Chain Transplantation Treatment Outcome 030220 oncology & carcinogenesis Immunology Disease Progression Female Immunoglobulin Light Chains Stem cell Multiple Myeloma business 030215 immunology |
| Zdroj: | Cancer Investigation. 35:195-201 |
| ISSN: | 1532-4192 0735-7907 |
| Popis: | We hypothesized the levels of free light chains obtained before and after autologous stem cell transplantation can be useful in predicting transplantation outcome. We analyzed 70 multiple myeloma patients. Abnormal free light chain ratios before stem cell transplantation were found to be associated early progression, although without any impact on overall survival. At day +30, the normalization of levels of involved free light chain related with early progression. According to these results almost one-third reduction of free light chain levels can predict favorable prognosis after autologous stem cell transplantation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |