Lower frequency of sister chromatid exchanges and altered frequency of HLA B-region alleles among individuals with sporadic dysplastic nevi
| Autor: | M. Di Lernia, Dario Rovini, M. T. Illeni, Natale Cascinelli, Achille Ghidoni |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Cancer Research Lymphocyte Clinical Biochemistry Sister chromatid exchange Human leukocyte antigen Biology Pathology and Forensic Medicine Dysplastic nevus syndrome Gene Frequency medicine HLA-B Antigens Humans Alleles Cells Cultured Melanoma Haplotype medicine.disease medicine.anatomical_structure Oncology Haplotypes Immunology Dysplastic nevus Female Dysplastic Nevus Syndrome Sister Chromatid Exchange |
| Zdroj: | The International journal of biological markers. 12(3) |
| ISSN: | 0393-6155 |
| Popis: | Sister chromatid exchanges (SCE) were analyzed in peripheral blood lymphocytes of 24 individuals, following diagnosis, and prior to surgical removal, of a sporadic dysplastic nevus (DN). Lower SCE values and variability were found in 23 sporadic DN individuals compared with controls (2.52+0.12 and 3.76±0.22 SCE/cell, respectively). These DN individuals, contrarily to healthy controls and some types of tumor patients whose cells are hypersensitive to mutagenic agents, did not show increased SCE rates as a consequence of cigarette smoking, alcohol consumption and diagnostic radiation treatments. These observations are in contrast with clinical evidence that similar lesions are both markers or risk and precursors of malignancy in individuals with multiple nevi, affected by the dysplastic nevus syndrome (DNS) or belonging to FMM (familial malignant melanoma) families. Three HLA class I alleles out of 72 tested were found more frequently in sporadic DN individuals compared with controls: B37 (p |
| Databáze: | OpenAIRE |
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