Wilms' Tumor in the Adult — Report of a Case and Review of the Literature

Autor: Jacob Briner, Jean-Pierre Droz, Arnaud D. Roth, Ayman Tawil, Sami Remadi, Jeremiah N. Cox
Rok vydání: 1999
Předmět:
Male
medicine.medical_specialty
Genes
Wilms Tumor
Lung Neoplasms
Adolescent
medicine.medical_treatment
Postoperative radiotherapy
Wilms Tumor
Nephrectomy
Pathology and Forensic Medicine
Immunoenzyme Techniques
Genes
Wilms Tumor/genetics
Antineoplastic Combined Chemotherapy Protocols
Tumor stage
Biomarkers
Tumor
medicine
Humans
Combined Modality Therapy
Grading (tumors)
Neoplasm Staging
Wilms Tumor/chemistry/genetics/secondary/therapy
ddc:616
Chemotherapy
Tumor Markers
Biological/analysis
ddc:617
business.industry
Wilms' tumor
Cell Biology
medicine.disease
Kidney Neoplasms
Surgery
Radiation therapy
Karyotyping
Kidney Neoplasms/chemistry/genetics/pathology/therapy
Lung Neoplasms/secondary/therapy
Antineoplastic Combined Chemotherapy Protocols/therapeutic use
Radiology
Tomography
X-Ray Computed
business
Zdroj: Pathology-Research and Practice, Vol. 195, No 2 (1999) pp. 105-11;discussion113-4
ISSN: 0344-0338
Popis: Wilms' tumor is rare in adults. Its histology, grading and staging are identical to those in children. Investigators agree on a combined modality approach in the treatment of adult Wilms' tumor (AWT), but differ on how aggressive it should be. Some advocate adopting the current pediatric protocols which take into account tumor stage and grade. Others recommend using advanced disease regimens for all stages and grades. We report on an 18 year-old male with stage IV favorable histology Wilms' tumor. The patient underwent radical nephrectomy and received postoperative radiotherapy with intensive four-drug chemotherapy. He had one relapse after 12 months which was successfully treated with chemotherapy and radiotherapy. He remains in remission without relapses 36 months after the initial diagnosis. The genetics of Wilms' tumor has been well studied in children but is practically unknown in adults; karyotype and molecular genetic studies in this case were normal.
Databáze: OpenAIRE
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