ALOX5, LPA, MMP9 and TPO gene polymorphisms increase atherothrombosis susceptibility in middle-aged Mexicans
| Autor: | Abraham Majluf-Cruz, Luisa Torres-Sánchez, Gino Noris, Carla Santana, Aurora de la Peña-Díaz, Rocío Gómez, Marco Antonio Meraz-Ríos, Esther Alhelí Hernández-Tobías, Jonathan J. Magaña, Lorena Orozco, Rafael Camacho-Mejorado, María de la Luz Arenas-Sordo |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
gene polymorphisms
Inflammation 030204 cardiovascular system & hematology medicine.disease_cause Population stratification 03 medical and health sciences 0302 clinical medicine Native Americans medicine Myocardial infarction lcsh:Science Stroke 030304 developmental biology Cause of death 0303 health sciences Multidisciplinary Genetic heterogeneity business.industry Lipid metabolism Genetics and Genomics medicine.disease stroke cardiovascular diseases multiloci studies myocardial infarction Immunology lcsh:Q medicine.symptom business Oxidative stress Research Article |
| Zdroj: | Royal Society Open Science Royal Society Open Science, Vol 7, Iss 1 (2020) |
| ISSN: | 2054-5703 |
| Popis: | Atherothrombosis is the cornerstone of cardiovascular diseases and the primary cause of death worldwide. Genetic contribution to disturbances in lipid metabolism, coagulation, inflammation and oxidative stress increase the susceptibility to its development and progression. Given its multifactorial nature, the multiloci studies have been proposed as potential predictors of susceptibility. A cross-sectional study was conducted to explore the contribution of nine genes involved in oxidative stress, inflammatory and thrombotic processes in 204 subjects with atherothrombosis matched by age and gender with a healthy group (n= 204). To evaluate the possibility of spurious associations owing to the Mexican population genetic heterogeneity as well as its ancestral origins, 300 unrelated mestizo individuals and 329 Native Americans were also included.ALOX5,LPA,MMP9andTPOgene polymorphisms, as well as their multiallelic combinations, were twice to four times more frequent in those individuals with clinical manifestations of atherothrombosis than in the healthy group. Once adjusting for population stratification was done, these differences remained. Our results add further evidence on the contribution ofALOX5,LPA,MMP9andTPOpolymorphisms to atherothrombosis development in the middle-aged group, emphasizing the multiethnic studies in search of gene risk polymorphisms. |
| Databáze: | OpenAIRE |
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