Simultaneous Occurrence of Kaposi's Sarcoma and Chronic Myelogenous Leukemia

Autor:	Dominique Maraninchi, Norbert Vey, Nathalie Petit, Slimane Dermeche, J. Camerlo, Luc Xerri
Rok vydání:	2001
Předmět:	Male Cancer Research medicine.medical_treatment CD4-CD8 Ratio Alpha interferon Vinblastine Serology Immune system HIV Seronegativity Leukemia Myelogenous Chronic BCR-ABL Positive hemic and lymphatic diseases Humans Medicine Sarcoma Kaposi Kaposi's sarcoma Aged business.industry Interferon-alpha Hematology medicine.disease Cytokine Oncology DNA Viral Herpesvirus 8 Human Immunology Sarcoma business medicine.drug Chronic myelogenous leukemia
Zdroj:	Leukemia & Lymphoma. 41:425-428
ISSN:	1029-2403 1042-8194
DOI:	10.3109/10428190109057999
Popis:	We report here a 75-year-old man from South France who developed Kaposi's Sarcoma (KS) 5 months after diagnosis of Philadelphia-chromosome positive chronic myelogenous leukemia (CML). He was found positive for HHV-8 by PCR, negative for both HIV 1 and HIV 2 by serology, and had a normal CD4/CD8 ratio. Favourable evolution of both CML and KS has been obtained with vinblastine and interferon alpha treatment. The patient is currently alive in complete remission of SK and major cytogenetic remission of CML with a 48 month follow-up. Since no immune deficiency could be documented in the patient, this rare observation suggests that CML may have triggered the onset of SK through cytokine release.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba712ba9eb9237cf1cbf9f95fc92b400 https://doi.org/10.3109/10428190109057999 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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