Heart rate variability and peripheral nerve conduction velocity in relation to blood lead in newly hired lead workers
| Autor: | Wen-Yi Yang, Fang-Fei Wei, Cai-Guo Yu, Blerim Mujaj, Jan A. Staessen, Lutgarde Thijs, Ying-Mei Feng, Zhen-Yu Zhang |
|---|---|
| Přispěvatelé: | Epidemiologie, RS: CARIM - R3.02 - Hypertension and target organ damage, RS: Carim - V02 Hypertension and target organ damage |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male NATIONAL-HEALTH medicine.medical_specialty Supine position materials exposures and occupational groups Neural Conduction UNITED-STATES PRESSURE 030204 cardiovascular system & hematology TOXICITY Nerve conduction velocity Standing Positions Electrocardiography 03 medical and health sciences 0302 clinical medicine Heart Rate Peripheral nerve Internal medicine medicine Humans Heart rate variability Peripheral Nerves EXPOSURE Workplace Lead (electronics) Trial registration Public Environmental & Occupational Health lead DECLINE Science & Technology healthcare workers business.industry cardiovascular Public Health Environmental and Occupational Health Blood Pressure Determination ADULTS 030210 environmental & occupational health Blood Pressure Determination/methods Electrocardiography/methods Female Heart Rate/physiology Lead/analysis Lead/blood Metallurgy/statistics & numerical data Neural Conduction/physiology Peripheral Nerves/metabolism Peripheral Nerves/physiology neurophysiology Median nerve Metallurgy Cardiology business Life Sciences & Biomedicine |
| Zdroj: | Occupational and Environmental Medicine Occupational and environmental medicine, vol. 76, no. 6, pp. 382-388 Occupational and Environmental Medicine, 76(6), 382-388. BMJ Publishing Group |
| ISSN: | 1470-7926 1351-0711 |
| Popis: | ObjectivesPrevious studies relating nervous activity to blood lead (BL) levels have limited relevance, because over time environmental and occupational exposure substantially dropped. We investigated the association of heart rate variability (HRV) and median nerve conduction velocity (NCV) with BL using the baseline measurements collected in the Study for Promotion of Health in Recycling Lead (NCT02243904).MethodsIn 328 newly hired men (mean age 28.3 years; participation rate 82.7%), we derived HRV measures (power expressed in normalised units (nu) in the high-frequency (HF) and low-frequency (LF) domains, and LF/HF) prior to long-term occupational lead exposure. Five-minute ECG recordings, obtained in the supine and standing positions, were analysed by Fourier transform or autoregressive modelling, using Cardiax software. Motor NCV was measured at the median nerve by a handheld device (Brevio Nerve Conduction Monitoring System, NeuMed, West Trenton, NJ, USA). BL was determined by inductively coupled plasma mass spectrometry.ResultsMean BL was 4.54 µg/dL (IQR 2.60–8.90 µg/dL). Mean supine and standing values of LF, HF and LF/HF were 50.5 and 21.1 nu and 2.63, and 59.7 and 10.9 nu and 6.31, respectively. Orthostatic stress decreased HF and increased LF (pConclusionsAt the exposure levels observed in our study, autonomous nervous activity and NCV were not associated with BL.Trial registration numberNCT02243904 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|