Clinical value of bronchodilator response for diagnosing asthma in steroid-naïve adults
| Autor: | Onni Niemelä, Pinja Ilmarinen, Leena E. Tuomisto, Minna Tommola, Hannu Kankaanranta, Lauri Lehtimäki |
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| Přispěvatelé: | Tampere University, Seinäjoen keskussairaala VA, BioMediTech, Department of Respiratory medicine, Dermatology and Allergology, Clinical Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
Spirometry medicine.medical_specialty medicine.diagnostic_test Adult patients medicine.drug_class business.industry 3121 Internal medicine medicine.disease Asthma respiratory tract diseases FEV1/FVC ratio Internal medicine Bronchodilator Original Research Articles Bronchodilation Cohort medicine Clinical value Medicine business |
| Zdroj: | ERJ Open Research article-version (VoR) Version of Record ERJ Open Research, Vol 7, Iss 4 (2021) |
| ISSN: | 2312-0541 |
| Popis: | Spirometry and testing for bronchodilator response have been recommended to detect asthma, and a bronchodilator response (BDR) of ≥12% and ≥200 mL has been suggested to confirm asthma. However, the clinical value of bronchodilation tests in newly diagnosed steroid-naïve adult patients with asthma remains unknown. We evaluated the sensitivity of BDR in forced expiratory volume in 1 s (FEV1) as a diagnostic test for asthma in a real-life cohort of participants in the Seinäjoki Adult Asthma Study. In the diagnostic phase, 369 spirometry tests with bronchodilation were performed for 219 steroid-naïve patients. The fulfilment of each test threshold was assessed. According to the algorithm of the National Institute for Health and Care Excellence, we divided the patients into obstructive (FEV1/forced vital capacity (FVC) In steroid-naïve adult patients with asthma, immediate bronchodilator response ΔFEV1 ≥12% and ≥200 mL has low diagnostic sensitivity for asthma https://bit.ly/3ut5eZ1 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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