18beta-glycyrrhetinic acid induces ROS-mediated apoptosis to ameliorate hepatic fibrosis by targeting PRDX1/2 in activated HSCs

Autor: Qian Zhang, Piao Luo, Liuhai Zheng, Jiayun Chen, Junzhe Zhang, Huan Tang, Dandan Liu, Xueling He, Qiaoli Shi, Liwei Gu, Jiahao Li, Qiuyan Guo, Chuanbin Yang, Yin Kwan Wong, Fei Xia, Jigang Wang
Rok vydání: 2022
Předmět:
Zdroj: Journal of Pharmaceutical Analysis. 12:570-582
ISSN: 2095-1779
Popis: Hepatic stellate cells (HSCs) are essential drivers of fibrogenesis. Inducing activated-HSC apoptosis is a promising strategy for treating hepatic fibrosis. 18beta-glycyrrhetinic acid (18β-GA) is a natural compound that exists widely in herbal medicines, such as
Databáze: OpenAIRE