Development of an acellular pertussis vaccine and its administration as a booster in healthy adults
| Autor: | A. Delem, A. Puttolaurila, Olli Ruuskanen, E. Simoen, Fe. Andre, De. Teuwen, André Noël, C. Capiau, Jean-Emmanuel Petre, Hugues Bogaerts, D. Vandevoorde |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male Bordetella pertussis Immunization Secondary Filamentous haemagglutinin adhesin Reversion complex mixtures medicine Humans Whooping cough Pertussis Vaccine General Veterinary General Immunology and Microbiology biology Immunogenicity Public Health Environmental and Occupational Health Toxoid Middle Aged Toxoids Hemagglutinin biology.organism_classification medicine.disease Antibodies Bacterial Virology Hemagglutinins Infectious Diseases Immunology biology.protein Molecular Medicine Female Antibody |
| Zdroj: | Vaccine. 9:117-121 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/0264-410x(91)90267-a |
| Popis: | An acellular pertussis vaccine which contains highly purified pertussis toxoid (PT) and filamentous haemagglutinin (FHA) has been developed. These proteins have been shown to be stable, with essentially no significant reversion of the pertussis toxoid after a new detoxification procedure. Two clinical trials using this vaccine as a booster in 45 healthy adults have been performed. Results show that the vaccine was well tolerated, causing essentially mild, transient symptoms after administration. It induced an increase in anti-PT and anti-FHA antibody titres in all vaccinees. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|