Risk for a second primary hypopharyngeal and esophageal cancer after an initial primary oral cancer

Autor: Chen Yang Hsu, Chiu Wen Su, Amy Ming Fang Yen, Cheng-Ping Wang, Sam Li Sheng Chen, Han-Mo Chiu, Shu Lin Chuang, William Wang Yu Su, Yi-Chia Lee, Sherry Yueh Hsia Chiu, Jean Ching Yuan Fann, Mu Kuan Chen, Hsiu Hsi Chen
Rok vydání: 2019
Předmět:
Zdroj: Oral Diseases. 25:1067-1075
ISSN: 1601-0825
1354-523X
DOI: 10.1111/odi.13080
Popis: Objective To investigate the risk for second primary cancer in the hypopharynx and esophagus (SPC-HE) among individuals with an initial oral/oropharyngeal cancer. Materials and methods Mass screening data from Taiwan (2004-2009) included individuals who were ≥18 years old and smoked cigarettes and/or chewed betel quid. Occurrence of SPC-HE was monitored until December 31, 2014. Results were expressed as adjusted relative risk (aRR) and 95% confidence interval (CI). Results One hundred and fifty-eight out of 4,494 subjects with oral cancer developed SPC-HE (incidence rate: 6.47 per 1,000 person-years). Relative to patients with primary cancers in the lip, the risk of an SPC-HE was higher in patients with primary cancers in oropharynx (aRR: 19.98, 95% CI: 4.72-84.55), floor of mouth (aRR: 12.13, 95% CI: 2.67-55.15), and hard palate (aRR: 7.31, 95% CI: 1.65-32.37), but not in patients with cancers in tongue (aRR: 3.67, 95% CI: 0.89-15.17) or gum (aRR: 3.99, 95% CI: 0.92-17.35). Regression analyses also showed the risk of an SPC-HE was greater in alcohol drinkers than those who did not (aRR: 1.65, 95% CI: 1.10-2.48). Conclusions Compared with the initial cancer in the lip, patients with a cancer in the oropharynx, floor of mouth, and hard palate had a higher risk for the SPC-HE.
Databáze: OpenAIRE
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