Non-invasive fractional flow reserve derived from coronary computed tomography angiography in patients with acute chest pain: Subgroup analysis of the ROMICAT II trial

Autor: Khristine Ghemigian, Michael T. Lu, Pamela K. Woodard, Udo Hoffmann, Alexander R. Ivanov, James E. Udelson, John T. Nagurney, Stefan Puchner, Maros Ferencik, Pál Maurovich-Horvat, Ting Liu, Quynh A. Truong, Elizabeth C. Adami, Thomas Mayrhofer
Rok vydání: 2018
Předmět:
Male
Acute coronary syndrome
medicine.medical_specialty
Computed Tomography Angiography
medicine.medical_treatment
Population
Hemodynamics
Subgroup analysis
Fractional flow reserve
030204 cardiovascular system & hematology
Chest pain
Revascularization
Coronary Angiography
Severity of Illness Index
Article
030218 nuclear medicine & medical imaging
Angina Pectoris
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
Internal medicine
medicine
Myocardial Revascularization
Humans
Radiology
Nuclear Medicine and imaging
Acute Coronary Syndrome
education
Randomized Controlled Trials as Topic
education.field_of_study
business.industry
Coronary Stenosis
Middle Aged
medicine.disease
Prognosis
Fractional Flow Reserve
Myocardial
Stenosis
Cardiology
Feasibility Studies
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Emergency Service
Hospital
Tomography
X-Ray Computed
Zdroj: J Cardiovasc Comput Tomogr
ISSN: 1876-861X
Popis: BACKGROUND: Non-invasive fractional flow reserve (FFR(CT)) derived from coronary computed tomography angiography (CTA) permits hemodynamic evaluation of coronary stenosis and may improve efficiency of assessment in stable chest pain patients. We determined feasibility of FFR(CT) in the population of acute chest pain patients and assessed the relationship of FFR(CT) with outcomes of acute coronary syndrome (ACS) and revascularization and with plaque characteristics. METHODS: We included 68 patients (mean age 55.8 ± 8.4 years, 71% men) from the ROMICAT II trial who had ≥50% stenosis on coronary CTA or underwent additional non-invasive stress test. We evaluated coronary stenosis and high-risk plaque on coronary CTA. FFR(CT) was measured in a core laboratory. RESULTS: We found correlation between anatomic severity of stenosis and FFR(CT) ≤0.80 vs. FFR(CT) >0.80 (severe stenosis 84.8% vs. 15.2%; moderate stenosis 33.3% vs. 66.7%; mild stenosis 33.3% vs. 66.7% patients). Patients with severe stenosis had lower FFR(CT) values (median 0.64, 25(th)-75(th) percentile 0.50–0.75) as compared to patients with moderate (median 0.84, 25(th)-75(th) percentile, p
Databáze: OpenAIRE
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