Theta and alpha oscillation impairments in autistic spectrum disorder reflect working memory deficit
| Autor: | Francisco Aboitiz, Claudia Herrera, Francisca Daiber, Josefina Larrain-Valenzuela, Ximena Carrasco, Pablo Billeke, Francisco Zamorano, Patricia Soto-Icaza |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Adolescent Autistic spectrum disorder Autism Spectrum Disorder lcsh:Medicine Alpha (ethology) Audiology Electroencephalography behavioral disciplines and activities Article 03 medical and health sciences Young Adult 0302 clinical medicine Cortex (anatomy) Task Performance and Analysis medicine Oscillation (cell signaling) Animals Humans Effects of sleep deprivation on cognitive performance Theta Rhythm lcsh:Science Psychiatry Memory Disorders Multidisciplinary medicine.diagnostic_test Working memory lcsh:R Brain Cognition Alpha Rhythm 030104 developmental biology medicine.anatomical_structure Memory Short-Term lcsh:Q Female Psychology 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports Artículos CONICYT CONICYT Chile instacron:CONICYT Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017) |
| Popis: | A dysfunction in the excitatory–inhibitory (E/I) coordination in neuronal assembly has been proposed as a possible neurobiological mechanism of Autistic Spectrum Disorder (ASD). However, the potential impact of this mechanism in cognitive performance is not fully explored. Since the main consequence of E/I dysfunction is an impairment in oscillatory activity and its underlying cognitive computations, we assessed the electroencephalographic activity of ASD and typically developing (TD) subjects during a working-memory task. We found that ASD subjects committed more errors than TD subjects. Moreover, TD subjects demonstrated a parametric modulation in the power of alpha and theta band while ASD subjects did not demonstrate significant modulations. The preceding leads to significant differences between the groups in both the alpha power placed on the occipital cortex and the theta power placed on the left premotor and the right prefrontal cortex. The impaired theta modulation correlated with autistic symptoms. The results indicated that ASD may present an alteration in the recruitment of the oscillatory activity during working-memory, and this alteration could be related to the physiopathology of the disorder. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|