Impact of common cardio-metabolic risk factors on fatal and non-fatal cardiovascular disease in Latin America and the Caribbean: an individual-level pooled analysis of 31 cohort studies

Autor: José Boggia, Alvaro Cc Maciel, Pablo Perel, Marselle B Amadio, Flávio Danni Fuchs, Jorge Tartaglione, Carla Do Bernardo, João Luiz Bastos, Jorge Salmerón, Claudia Bambs, Karen Oppermann, Gilbert Brenes-Camacho, J. Jaime Miranda, Poli Mara Spritzer, Nohora I Rodriguez, Oscar Muñoz, Pollyanna Kássia de Oliveira Borges, Edward W. Gregg, Laura Gutierrez, Ramon A Sanchez, Walter G Espeche, Paula Ramírez-Palacios, Rodrigo M. Carrillo-Larco, Juan E. Blümel, Nelson A S Silva, Marco Aurélio Peres, Leila Beltrami Moreira, Martin Lajous, Clicerio González-Villalpando, Eleonora d'Orsi, Karina Mary de Paiva, Sérgio Viana Peixoto, Alexandre C. Pereira, Majid Ezzati, Betty S Manrique-Espinoza, Miguel Bravo, Ramón Álvarez-Vaz, Maria S. Castillo Rascon, Suely Ga Gimeno, Luis Rosero-Bixby, Rosalba Rojas-Martínez, Elard Koch, Ricardo Oliveira Guerra, Dalia Stern, Anselm Hennis, Vilma Irazola, Aaron Salinas-Rodriguez, Catterina Ferreccio, Carlos A. Aguilar-Salinas, Paulo A. Lotufo, Blanca H. Ceballos, Goodarz Danaei, Cassiano Ricardo Rech, Donaji Gomez-Velasco, Adrian Cortes-Valencia, Thiago L N Silva, Andrea R. V. R. Horimoto, Adolfo Rubinstein, Mariachiara Di Cesare, Cecilia Baccino, Roberto de Sa Cunha, Liam Smeeth, Verônica Colpani, Sandra C. Fuchs, Maria Fernanda Lima-Costa, Larissa Pruner Marques, Ruy Lopez-Ridaura, Gonzalo Grazioli, Horacio A Carbajal, Andrea Huidobro, Sandra Cortés, Karen Glazer Peres, Berenice Rivera-Paredez, Antonio Bernabe-Ortiz, Martin R Salazar, Álvaro Ruiz-Morales, José Geraldo Mill, Ian Hambleton, María-Elena González-Villalpando, Gloria L. Beckles, William H. Dow, Fiorella Tartaglione, David Alejandro González-Chica, Jackie A. Cooper, Rafael Velázquez-Cruz, Katia Vergetti Bloch, Lariane M Ono, Fernando Luiz Herkenhoff
Přispěvatelé: Wellcome Trust
Rok vydání: 2021
Předmět:
Zdroj: Lancet Regional Health. Americas
The Lancet Regional Health. Americas, Vol 4, Iss, Pp 100068-(2021)
ISSN: 2667-193X
Popis: Background: Estimates of the burden of cardio-metabolic risk factors in Latin America and the Caribbean (LAC) rely on relative risks (RRs) from non-LAC countries. Whether these RRs apply to LAC remains unknown. Methods: We pooled LAC cohorts. We estimated RRs per unit of exposure to body mass index (BMI), systolic blood pressure (SBP), fasting plasma glucose (FPG), total cholesterol (TC) and non-HDL cholesterol on fatal (31 cohorts, n=168,287) and non-fatal (13 cohorts, n=27,554) cardiovascular diseases, adjusting for regression dilution bias. We used these RRs and national data on mean risk factor levels to estimate the number of cardiovascular deaths attributable to non-optimal levels of each risk factor. Results: Our RRs for SBP, FPG and TC were like those observed in cohorts conducted in high-income countries; however, for BMI, our RRs were consistently smaller in people below 75 years of age. Across risk factors, we observed smaller RRs among older ages. Non-optimal SBP was responsible for the largest number of attributable cardiovascular deaths ranging from 38 per 100,000 women and 54 men in Peru, to 261 (Dominica, women) and 282 (Guyana, men). For non-HDL cholesterol, the lowest attributable rate was for women in Peru (21) and men in Guatemala (25), and the largest in men (158) and women (142) from Guyana. Interpretation: RRs for BMI from studies conducted in high-income countries may overestimate disease burden metrics in LAC; conversely, RRs for SBP, FPG and TC from LAC cohorts are similar to those estimated from cohorts in high-income countries. Funding: Wellcome Trust (214185/Z/18/Z)
Databáze: OpenAIRE
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