Factors associated with serum thyroglobulin in a Ukrainian cohort exposed to iodine-131 from the accident at the Chernobyl Nuclear Plant

Autor: Vladimir Drozdovitch, Mykola Tronko, Maureen Hatch, Valeriy Oliynyk, Kiyohiko Mabuchi, Galyna Terekhova, Elizabeth K. Cahoon, Victor Shpak, Kamau O. Peters, Ruth M. Pfeiffer, Mark P. Little, Lydia B. Zablotska, Robert J. McConnell, Alina V. Brenner
Rok vydání: 2017
Předmět:
Male
endocrine system diseases
medicine.medical_treatment
Thyroid Gland
Thyrotropin
Toxicology
Biochemistry
Iodine Radioisotopes
0302 clinical medicine
Blood serum
General Environmental Science
Thyroid
education.field_of_study
Thyroid disease
Smoking
Age Factors
Chemobyl
Radiation Exposure
Biological Sciences
medicine.anatomical_structure
030220 oncology & carcinogenesis
Biomarker (medicine)
Female
Ukraine
Iodine
Adult
Ionizing radiation
medicine.medical_specialty
endocrine system
Adolescent
Population
chemistry.chemical_element
030209 endocrinology & metabolism
Radiation Dosage
Thyroglobulin
Chernobyl
Vaccine Related
03 medical and health sciences
Young Adult
Internal medicine
medicine
Humans
education
business.industry
medicine.disease
Iodine deficiency
Diet
Endocrinology
chemistry
Chernobyl Nuclear Accident
Chemical Sciences
business
Environmental Sciences
Zdroj: Peters, KO; Tronko, M; Hatch, M; Oliynyk, V; Terekhova, G; Pfeiffer, RM; et al.(2017). Factors associated with serum thyroglobulin in a Ukrainian cohort exposed to iodine-131 from the accident at the Chernobyl Nuclear Plant. ENVIRONMENTAL RESEARCH, 156, 801-809. doi: 10.1016/j.envres.2017.04.014. UCSF: Retrieved from: http://www.escholarship.org/uc/item/30n8q53r
Popis: BackgroundSerum thyroglobulin (Tg) is associated with the presence of thyroid disease and has been proposed as a biomarker of iodine status. Few studies have examined factors related to serum Tg in populations environmentally exposed to ionizing radiation and living in regions with endemic mild-to-moderate iodine deficiency.MethodsWe screened 10,430 individuals who were living in Ukraine and under 18 years of age at the time of the 1986 Chernobyl Nuclear Power Plant accident for thyroid disease from 2001 to 2003. We estimated the percent change (PC) in serum Tg associated with demographic factors, iodine-131 thyroid dose, and indicators of thyroid structure and function using linear regression. We also examined these relationships for individuals with and without indications of thyroid abnormality.ResultsMean and median serum Tg levels were higher among participants with abnormal thyroid structure/function. Percent change in serum Tg increased among females, smokers and with older age (p-values
Databáze: OpenAIRE
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