Spontaneous C. septicum gas gangrene: A literature review
| Autor: | Ira Srivastava, Michael J. Aldape, Dennis L. Stevens, Amy E. Bryant |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Neutropenia Malignancy Microbiology Gross examination 03 medical and health sciences 0302 clinical medicine medicine Clostridium septicum Humans 030212 general & internal medicine biology business.industry Disease Management Immunosuppression medicine.disease biology.organism_classification Dermatology Pathophysiology Surgery Infectious Diseases Infectious disease (medical specialty) 030220 oncology & carcinogenesis Disease Susceptibility business Gas Gangrene Gas gangrene |
| Zdroj: | Anaerobe. 48 |
| ISSN: | 1095-8274 |
| Popis: | As the infectious disease paradigm undergoes a subtle shift, unusual infections associated with malignancy and immunosuppression are being increasingly reported. Spontaneous or non-traumatic Clostridium septicum infection is one such unusual infection which has gained prominence. This article aims to understand the pathophysiology, clinical manifestations and current trends in diagnosing and treating this rare but deadly infection. To understand the multifactorial causation of this infection a review of published cases of spontaneous C. septicum gas gangrene was performed and a total of 94 such cases were identified. Several factors were analyzed for each case: age, infection location and underlying illness, presenting signs and symptoms, neutropenia, gross pathology of the colon, antibiotic use, surgical intervention, and survival. A known or occult malignancy was present in 71% patients and an overall mortality of 67% was observed. |
| Databáze: | OpenAIRE |
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