Successful simultaneous pancreas kidney transplantation from living-related donor against positive cross-match
| Autor: | Cinzia Sammartino, Enrico Benedetti, Howard Sankary, Fabrizio Panaro, Thuy Pham, Giuliano Testa, Diego Bogetti, Nicola Morelli, Tomasz Jarzembowski |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Graft Rejection medicine.medical_specialty medicine.drug_class medicine.medical_treatment Monoclonal antibody Living donor Transplantation Immunology Living Donors Immunology and Allergy Medicine Humans Pharmacology (medical) Pancreas Transplantation biology business.industry Living related donor Histocompatibility Testing Simultaneous pancreas kidney transplantation Graft Survival Antibodies Monoclonal Immunoglobulins Intravenous Plasmapheresis Antigens CD20 Flow Cytometry Kidney Transplantation Surgery Diabetes Mellitus Type 1 Donation biology.protein Kidney Failure Chronic Female Pancreas Transplantation Antibody business |
| Zdroj: | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 4(1) |
| ISSN: | 1600-6135 |
| Popis: | A positive pretransplant flow cytometry cross-match (FC-XM) allows precise identification of high-risk recipients vulnerable to hyperacute or accelerated rejection after transplantation. Living donor kidney transplant recipient candidates with positive cross-match have been successfully treated with a combination of plasmapheresis (therapeutic plasma exchange, TPEX) and intravenous immunoglobulin (IVIG), achieving conversion to negative cross-match and successful transplant. We report the first successful case of simultaneous pancreas kidney transplant (SPKT) from a living donor (LD) performed against an initially positive FC-XM, converted to negative using a protocol based on TPEX and IVIG in combination with antiCD20 monoclonal antibody. This strategy of overcoming the cross-match barriers in living donation may offer a chance of successful transplantation to highly sensitized candidates for SPKT, for whom cadaveric transplant is difficult to achieve. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text