Circulating levels of bisphenol A (BPA) and phthalates in an elderly population in Sweden, based on the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS)
Autor: | Erik Lampa, Lars Lind, Lena Olsén, P. Monica Lind, Detlef A. Birkholz |
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Rok vydání: | 2012 |
Předmět: |
Male
endocrine system medicine.medical_specialty Bisphenol A Health Toxicology and Mutagenesis Population Phthalic Acids Toxicology chemistry.chemical_compound Phenols Tandem Mass Spectrometry Elderly population Internal medicine medicine Humans Prospective Studies Benzhydryl compounds Benzhydryl Compounds education Chromatography High Pressure Liquid Aged Sweden education.field_of_study Monomethyl phthalate Public Health Environmental and Occupational Health Phthalate Environmental Exposure General Medicine Environmental exposure Pollution Phthalic acid Endocrinology chemistry Environmental Pollutants Female |
Zdroj: | Ecotoxicology and Environmental Safety. 75:242-248 |
ISSN: | 0147-6513 |
Popis: | The plastic manufacture compounds, bisphenol A (BPA) and phthalates, are ubiquitous and have therefore been detected in virtually all types of analyzed human samples. The aim of this study was: (1) to investigate concentrations of serum levels of BPA and phthalate metabolites in seniors residing in the city of Uppsala, Sweden (2) to evaluate gender differences in relation to serum levels of BPA and phthalate metabolites in the subjects. In the population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS), encompassing 1016 subjects, all aged 70, serum levels of BPA and phthalate metabolites were measured by Isotope Dilution-High Performance Liquid Chromatography-Tandem Mass Spectrometry. BPA and four out of ten phthalate metabolites, namely, Monoisobutyl phthalate (MiBP), Monomethyl phthalate (MMP), Monoethyl phthalate (MEP), Mono-(2-ethylhexyl) phthalate (MEHP), were detectable in almost all subjects. Of the remaining phthalate metabolites, Monobenzyl phthalate (MBzP), Mono-(2-ethyl-5-hydroxyhexyl) phthalate (MeHHP), and Mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) were seen in some 300-700 of the subjects, whereas Monoisononyl phthalate (MINP) and Mono-n-octyl phthalate (MOP) were found in only a few and Monocyclohexyl phthalate (MCHP) was not detected in any subject. Neither the circulation levels of BPA nor those of phthalate metabolites differ between the genders in this elderly population of residents in Uppsala, Sweden. |
Databáze: | OpenAIRE |
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