Corneal and Anterior Chamber Morphology in Human Immunodeficiency Virus-1-Infected Patients Without Opportunistic Infections
| Autor: | Ebru Nevin Çetin, Murat Kutlu, Osman Parca, Selda Sayin Kutlu, Gökhan Pekel |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine genetic structures Human immunodeficiency virus (HIV) Human immunodeficiency virus 1 Cell Count HIV Infections medicine.disease_cause law.invention Cornea 0302 clinical medicine law middle aged Photography endothelium cell Prospective Studies Prospective cohort study Microscopy Age Factors Healthy subjects Adult Aged Anterior Chamber/*pathology Case-Control Studies Cornea/*pathology Endothelial Cells/cytology Female HIV Infections/*pathology/virology HIV-1 Humans Middle Aged Young Adult virology female medicine.anatomical_structure Corneal endothelial cell density prospective study medicine.medical_specialty Anterior Chamber Coefficient of variation 03 medical and health sciences Human immunodeficiency virus infection Ophthalmology medicine human anterior eye chamber Keratometer business.industry Case-control study Endothelial Cells case control study eye diseases 030104 developmental biology age cytology 030221 ophthalmology & optometry pathology sense organs business |
| Popis: | OBJECTIVES: To evaluate corneal and anterior chamber morphology as measured by Pentacam HR in human immunodeficiency virus (HIV)-infected patients without opportunistic infections and to search for signs of accelerated aging. METHODS: This prospective study included 41 eyes of 41 HIV-1-infected patients (study group) and 50 eyes of 50 healthy subjects (control group). Specular microscope and Pentacam HR were used for corneal and anterior chamber morphology evaluation. Corneal endothelial cell density (CECD), hexagonal cell ratio, coefficient of variation, corneal thickness, density and volume, maximum keratometry, anterior chamber volume (ACV), and anterior chamber depth (ACD) measurements were recorded for analysis. RESULTS: The mean CD4 count was 428.3±231.9 (36-950) cells/mL, and the time since diagnosis was 27.5±34.1 months in the study group. The difference in anterior segment parameters was not significantly different between the study and the control groups (P>0.05). Age significantly correlated with CECD (r=-0.436, P=0.004), ACV (r=-0.570, P |
| Databáze: | OpenAIRE |
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