Endothelins Mediate Intestinal Hypoperfusion during Bacteremia
| Autor: | Glen Steeb, Mark A. Wilson, Richard N. Garrison |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.hormone Bacteremia Pharmacology Biology Rats Sprague-Dawley Endothelins medicine Animals Escherichia coli Infections medicine.disease Recombinant Proteins Small intestine Pathophysiology Rats Intestines Arterioles medicine.anatomical_structure Vasoconstriction Immunology cardiovascular system Surgery medicine.symptom Endothelin receptor Perfusion Intravital microscopy |
| Zdroj: | Journal of Surgical Research. 55:168-175 |
| ISSN: | 0022-4804 |
| DOI: | 10.1006/jsre.1993.1125 |
| Popis: | We have previously reported that Escherichia coli bacteremia induces hypoperfusion and vasoconstriction of the rat small intestinal microcirculation. However, the mechanisms which mediate these responses are not clearly defined. Because serum levels of endothelins, a family of potent vasoconstrictor peptides, are increased during bacteremia, we postulated that endothelins contribute to intestinal hypoperfusion during infection. Using intravital microscopy, we characterized the effects of topically applied recombinant endothelin-1 on small intestinal arteriolar diameters and blood flow. Dose-dependent vasoconstriction of both large (A1) and small (A3) arterioles and hypoperfusion were observed. To assess whether endothelins contribute to alterations of the intestinal microcirculation during bacteremia, antiserum was used to inhibit endothelins during E. coli bacteremia. Endothelin inhibition resulted in restoration of blood flow and attenuation of vasoconstriction. Our results suggest that endothelins contribute to intestinal hypoperfusion and arteriolar vasoconstriction during bacteremia. |
| Databáze: | OpenAIRE |
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