Evaluation of chlorambucil therapy in steroid-dependent and cyclophosphamide-resistant children with nephrosis
| Autor: | O. P. Jaiswal, Abdelaziz Y. Elzouki |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Nephrology
Male medicine.medical_specialty Cyclophosphamide Adolescent Nephrosis Drug Resistance Gastroenterology Focal segmental glomerulosclerosis Internal medicine medicine Humans Life Tables Prospective Studies Prospective cohort study Child Chlorambucil business.industry Infant Glomerulonephritis medicine.disease Endocrinology Child Preschool Pediatrics Perinatology and Child Health Prednisone Female business Nephrotic syndrome medicine.drug |
| Zdroj: | Pediatric nephrology (Berlin, Germany). 4(5) |
| ISSN: | 0931-041X |
| Popis: | A prospective study was performed to evaluate the efficacy of chlorambucil in inducing long-term remission in children with steroid-dependent or cyclophosphamide-resistant primary nephrotic syndrome (NS). The 16 steroid-dependent children had a relapse rate of 5.3/patient per year (range 4-8) and a mean age of 8.4 years (range 2-13). The chlorambucil dosage was 0.2 mg/kg per day for a total of 8 weeks. Nine patients (56%) remained in complete remission for an average of 39.2 months (range 16-70). The interval to the first relapse in the remaining 7 ranged from 4 to 41 months and the relapse rate decreased significantly to 0.6 relapses/patient per year (P less than 0.05). Five children had steroid- and cyclophosphamide-resistant NS, 4 with focal segmental glomerulosclerosis and 1 with mesangiol proliferative glomerulonephritis. Chlorambucil was given in a dose of 0.2 mg/kg per day for 8-16 weeks. Complete remission was obtained in 4 patients; 2 patients relapsed. No serious long-term complications were observed in our patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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