Association of p155/140 Autoantibody With Loss of Nailfold Capillaries but not Generalized Lipodystrophy: A Study of Ninety‐Six Children With Juvenile Dermatomyositis
| Autor: | Gabrielle A. Morgan, Amer Khojah, Victoria Liu, Sonia I Savani, Lauren M. Pachman, Jackie Bellm, Richard M. Shore |
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| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
Lipodystrophy Myositis business.industry Generalized lipodystrophy Significant difference Geriatric assessment Fat distribution medicine.disease Trunk Gastroenterology Dermatomyositis Capillaries Rheumatology Internal medicine medicine Humans Population study business Juvenile dermatomyositis Autoantibodies |
| Zdroj: | Arthritis Care & Research. 74:1065-1069 |
| ISSN: | 2151-4658 2151-464X |
| DOI: | 10.1002/acr.24535 |
| Popis: | Myositis-specific antibodies (MSAs) facilitate grouping children with juvenile dermatomyositis (DM) into distinct phenotypes. The first aim of this study was to investigate the link between anti-p155/140 and lipodystrophy as determined by dual x-ray absorptiometry (DXA) assessment of fat distribution. The second aim was to examine the relationship between anti-p155/140 and damage to the nailfold capillary system.Children with juvenile DM followed for a minimum of 5 years were included. The study population was divided into 3 groups (anti-p155/140, other MSA, and MSA negative). Lipodystrophy was assessed by physician assessment and DXA fat distribution (trunk-to-leg fat ratio). Documentation of nailfold capillary end row loops (ERLs) was obtained at diagnosis.A total of 96 subjects (44% anti-p155/140, 23% other MSA, 33% MSA negative) were included. There was no significant difference in age, disease activity scores, or lipodystrophy between the 3 groups. The trunk-to-leg fat ratios were similar among the 3 groups at different time points. However, the anti-p155/140 group had significantly decreased ERL counts (P = 0.006) at baseline as well as a prolonged duration of untreated disease at diagnosis (P = 0.027). Also, the anti-p155/140 group had fewer patients with a monophasic disease course than the other 2 groups (P = 0.008).Generalized lipodystrophy frequency was equivalent in all 3 groups based on physician assessments and trunk-to-leg fat ratios. The anti-p155/140 group had a greater loss of ERLs, suggesting that this MSA may impact the vascular component of juvenile DM. |
| Databáze: | OpenAIRE |
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