The CYP19A1 rs3751592 variant confers susceptibility to Alzheimer disease in the Chinese Han population
| Autor: | Li Xie, Mukun Huang, Yanying Kong, Jin Li, Jiaqiang Zheng, Shujin Zhao, Lei Shi, Yongpan Zhao, Huacheng Yan, Jian Li |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Apolipoprotein E Male endocrine system Apolipoprotein E4 Polymorphism Single Nucleotide CYP 19A1 03 medical and health sciences 0302 clinical medicine Aromatase Asian People Polymorphism (computer science) Alzheimer Disease single nucleotide polymorphism Genotype medicine Humans Genetic Predisposition to Disease apolipoprotein E ε4 Allele Gene Genetics Aged 80 and over biology business.industry Case-control study General Medicine Clinical Trial/Experimental Study medicine.disease 030104 developmental biology Case-Control Studies biology.protein Female Alzheimer's disease business 030217 neurology & neurosurgery Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | Background: The CYP19A1 enzyme (aromatase) encoded by the cytochrome P450 (CYP) 19A1 gene influences the final step in the biosynthesis of estrogen, which has been associated with Alzheimer disease (AD). It is possible that genetic polymorphisms in CYP19A1 could influence the risk of AD by altering the expression of CYP19A1. The ε4 allele of the apolipoprotein E (APOE) gene, which is the most significant known genetic risk factor for AD, may mask the effects of other loci. Methods: To assess the potential association of CYP19A1 gene polymorphisms with the risk of AD, we conducted a case–control study in a Chinese Han population by recruiting 463 cases, including 207 patients diagnosed with AD and 256 healthy people matched for sex and age. Results: In APOE ε4 carriers, the distributions of the G allele and the AG + GG genotype of CYP19A1 rs3751592 in patients differed significantly (P |
| Databáze: | OpenAIRE |
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