A study of pseudocholinesterase induction in experimental obesity
| Autor: | S N Huang, K M Kutty, K T Kean, R Jain |
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| Rok vydání: | 1986 |
| Předmět: |
Male
medicine.medical_specialty Medicine (miscellaneous) Biology Endoplasmic Reticulum Protein content Mice Internal medicine High fat medicine Dietary Carbohydrates Animals Cholinesterases Restricted diet Obesity Nutrition and Dietetics Histocytochemistry Endoplasmic reticulum Carbohydrate medicine.disease Dietary Fats Staining Mice Inbred C57BL Microscopy Electron Endocrinology Liver Butyrylcholinesterase Enzyme Induction Dietary Proteins |
| Zdroj: | Journal of the American College of Nutrition. 5(3) |
| ISSN: | 0731-5724 |
| Popis: | Liver pseudocholinesterase (PChE) activity was significantly higher in genetically obese (ob/ob) mice than in lean littermates as early as 23 days after birth. By cytochemical electron microscopy, increased staining for PChE was observed in the rough endoplasmic reticulum of ob/ob mice. Albino mice with different diets showed that high-protein diets produced the greatest increase in PChE activity in the liver compared to carbohydrate or high fat. Mice fed a normal mouse diet ad lib had significantly higher liver PChE activity than those fed a restricted diet of 2 g of a normal mouse chow per day. In albino mice liver PChE activity varied directly with the protein content in the diet. These studies suggest that liver PChE induction is a function of the level of protein in the diet. |
| Databáze: | OpenAIRE |
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