De-regulation of diabetic regulatory genes in psoriasis: Deciphering the unsolved riddle
| Autor: | Suad AlFadhli, Nawaf Al-Mutairi, Rasheeba Nizam, Alaa A.M. Al-Zufairi, Huda A. AlSaffar |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Oncology medicine.medical_specialty Candidate gene endocrine system diseases Disease Biology Pathogenesis 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus Psoriasis Genetics medicine Humans Gene Regulator gene Protein Tyrosine Phosphatase Non-Receptor Type 1 Glycogen Synthase Kinase 3 beta Qa-SNARE Proteins General Medicine Middle Aged medicine.disease 030104 developmental biology Diabetes Mellitus Type 2 Gene Expression Regulation Female PTPN1 Biomarkers |
| Zdroj: | Gene. 593:110-116 |
| ISSN: | 0378-1119 |
| DOI: | 10.1016/j.gene.2016.08.024 |
| Popis: | The purpose of our study was to identify the currently lacking molecular mechanism that accounts for the co-occurrence of two seemingly disparate diseases: psoriasis and type II diabetes. We aimed to investigate a panel of 84 genes related to the diabetic regulatory network in psoriasis (Ps), psoriasis type II diabetes (Ps-T2D), type II diabetes (T2D) and healthy control (HC). We hypothesize that such attempts would provide novel diagnostic markers and/or insights into pathogenesis of the disease. A quantitative Real Time-PCR Human Diabetes RT2 Profiler PCR Array was chosen to explore the expression profile 84 diabetic genes in study subjects. Statistical analysis was carried out using appropriate software. The analysis revealed three candidate genes GSK3B, PTPN1, STX4 that are differentially expressed in study subjects. GSK3B was highly significant in Ps-T2D (P = 0.00018, FR = − 26.6), followed by Ps (P = 0.0028, FR = − 14.5) and T2D groups (P = 0.032, FR = − 5.9). PTPN1 showed significant association only with PS-T2D (P = 0.00027, FR = − 8.5). STX4 showed significant association with both Ps (P = 0.0002, FR = − 20) and Ps-T2D (P = 0.0016, FR = − 11.2). ACE represents an additional marker that showed suggestive association with Ps (P = 0.0079, FR = − 9.37). Our study highlights the complex genetics of Ps-T2D and present biomarkers for the development of T2D in Ps cases. |
| Databáze: | OpenAIRE |
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