Inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers

Autor: Alexandra Sotiros, Jennifer A. Armstrong, Dianne Thornhill, Virginia D. Winn, Miriam D. Post
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Embryology
Physiology
Maternal Health
Placenta
Developmental and Pediatric Neurology
Pediatrics
Fetal Development
Families
Pre-Eclampsia
Pregnancy
Immune Physiology
Medicine and Health Sciences
Pediatric stroke
Prospective Studies
Immune Response
Children
Innate Immune System
Multidisciplinary
Obstetrics
Gestational age
Obstetrics and Gynecology
Middle Aged
Fetal Blood
Body Fluids
Up-Regulation
medicine.anatomical_structure
Blood
Neurology
Cohort
embryonic structures
Cytokines
Premature Birth
Medicine
Female
Anatomy
Infants
Research Article
Maternal Age
Adult
medicine.medical_specialty
Science
Immunology
Gestational Age
Preeclampsia
Proinflammatory cytokine
Young Adult
Signs and Symptoms
medicine
Humans
Risk factor
Inflammation
Fetus
business.industry
Interleukin-6
Reproductive System
Infant
Newborn
Biology and Life Sciences
Neonates
Molecular Development
medicine.disease
Pregnancy Complications
Age Groups
Immune System
People and Places
Women's Health
Population Groupings
Clinical Medicine
business
Developmental Biology
Zdroj: PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 11, p e0260094 (2021)
ISSN: 1932-6203
Popis: Preeclampsia is both a vascular and inflammatory disorder. Since the placenta is a conduit for fetal development, preeclampsia should be a presumed cause of adverse infant outcomes. Yet, the relationship of placental pathology, inflammation and neurological outcomes after preeclampsia are understudied. We prospectively examined a cohort of maternal-infant dyads with preeclampsia for maternal inflammatory cytokines at time of preeclampsia diagnosis and delivery, and fetal cord blood cytokines (IL-1β, IL-6, IL-8, and TNF-α). Placentas were analyzed for inflammatory and vascular pathologies. Neurodevelopmental assessment of infants utilizing the Pediatric Stroke Outcome Measure (PSOM) was conducted at 6-month corrected gestational age. Eighty-one maternal-newborn dyads were examined. Worse neurological outcomes were not associated with elevated maternal / fetal cytokines. Early preterm birth (gestational age ≤ 32 weeks) was associated with worse neurological outcomes at 6-months regardless of maternal/ fetal cytokine levels, placental pathology, or cranial ultrasound findings (OR 1.70, [1.16–2.48], p = 0.006). When correcting for gestational age, elevated IL-6 approached significance as a predictor for worse developmental outcome (OR 1.025 [0.985–1.066], p = 0.221). Pathological evidence of maternal malperfusion and worse outcomes were noted in early preterm, although our sample size was small. Our study did not demonstrate an obvious association of inflammation and placental pathology in preeclampsia and adverse neurodevelopmental outcome at 6-month corrected age but does suggest maternal malperfusion at earlier gestational age may be a risk factor for worse outcome.
Databáze: OpenAIRE
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