Developmental Toxicity of Diethanolamine Applied Cutaneously to CD Rats and New Zealand White Rabbits
| Autor: | Mary Sue Marty, E. W. Carney, D A Neptun, T L Neeper-Bradley |
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| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Anemia Microcytic anemia Developmental toxicity Gestational Age Biology Administration Cutaneous Toxicology Eating Embryonic and Fetal Development Pregnancy Internal medicine medicine Animals Skin Fetus Dose-Response Relationship Drug Body Weight Abnormalities Drug-Induced General Medicine medicine.disease Teratology Rats Dose–response relationship Endocrinology Ethanolamines Toxicity Dermatitis Irritant Gestation Female Rabbits |
| Zdroj: | Regulatory Toxicology and Pharmacology. 30:169-181 |
| ISSN: | 0273-2300 |
| DOI: | 10.1006/rtph.1999.1308 |
| Popis: | Diethanolamine (DEA) was administered cutaneously to pregnant CD rats and New Zealand White rabbits during the periods of major organogenesis, Gestation Days 6-15 for rats and 6-18 for rabbits. Doses employed were 0, 150, 500, and 1500 mg/kg/day for rats and 0, 35, 100, and 350 mg/kg/day for rabbits. Rat dams exhibited reduced body weight at 1500 mg/kg/day, skin irritation and increased kidney weights at 500 and 1500 mg/kg/day, and a slight microcytic anemia with abnormal red blood cell morphology at all dose levels. Rat fetuses had increased incidences of six skeletal variations at 1500 mg/kg/day. Lower doses were without effect on the fetuses. Rabbit dams administered 350 mg/kg/day exhibited various skin lesions, reduced food consumption, and color changes in the kidneys but no hematological changes. Body weight gain was reduced at >/=100 mg/kg/day. There was no evidence of maternal toxicity at 35 mg/kg/day and no evidence of developmental toxicity in rabbits at any dose level. Developmental toxicity was observed only in the rat and only at doses causing significant maternal toxicity, including hematological effects. Due to a dose discrepancy, the no observable effect level (NOEL) for DEA developmental toxicity in rats was adjusted to 380 mg/kg/day. In rabbits, the embryonal/fetal NOEL was 350 mg/kg/day. |
| Databáze: | OpenAIRE |
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